MnTMPyP Pentachloride, SOD/Catalase mimetic (ab142212)

Submit a review Q&A (1)References (1)

Overview

  • Product name

    MnTMPyP Pentachloride, SOD/Catalase mimetic

  • Description

    Cell-permeable SOD/Catalase mimetic

  • Biological description

    Cell-permeable SOD/Catalase mimetic. Catalyzes dismutation of superoxide. Peroxynitrite inhibitor. Oxidative stress inhibitor. Active in vitro and in vivo.

  • Purity

    > 96%

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)-21H,23H-porphyrin manganese(III) pentachloride

  • Molecular weight

    909.01

  • Molecular formula

    Mn(C44H36N8)Cl5

  • PubChem identifier

    4233

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in water

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[N+]1=CC=C(C=C1)C2=C3C=CC(=C(C4=NC(=C(C5=CC=C([N-]5)C(=C6C=CC2=N6)C7= CC=[N+](C=C7)C)C8=CC=[N+](C=C8)C)C=C4)C9=CC=[N+](C=C9)C)[N-]3.[Mn+3]

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Seija M  et al. Role of peroxynitrite in sepsis-induced acute kidney injury in an experimental model of sepsis in rats. Shock 38:403-10 (2012). Read more (PubMed: 22777123) »
  • Maenpaa CJ  et al. Oxidant-mediated apoptosis in proximal tubular epithelial cells following ATP depletion and recovery. Free Radic Biol Med 44:518-26 (2008). Read more (PubMed: 17997382) »
  • Sharma SS & Gupta S Neuroprotective effect of MnTMPyP, a superoxide dismutase/catalase mimetic in global cerebral ischemia is mediated through reduction of oxidative stress and DNA fragmentation. Eur J Pharmacol 561:72-9 (2007). Read more (PubMed: 17320858) »
See 1 Publication for this product

Publishing research using ab142212? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

Question

How should this be reconsituted and stored for maximum stability?

Read More
Answer

I am sorry to report I was not able to find any stability data for MnTMPyP. The paper at the following link discusses stability under assay conditions but not storage. It appears to be the earliest reference for this compound.


http://www.jbc.org/content/269/38/23471.full.pdf

J Biol Chem. 1994 Sep 23;269(38):23471-6.

Other vendors specify a limit of 3 months at -20C after reconstitution in water as a guideline for storage.

It will go into solution in DMSO but it is not clear that it will be any more stable in DMSO than in water. The study in the following reference used a DMSO solution, for example, figure 4.

http://www.ncbi.nlm.nih.gov/pubmed/?term=9832148
J Neurochem. 1998 Dec;71(6):2497-504.

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com