MnTMPyP Pentachloride, SOD/Catalase mimetic (ab142212)

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Key features and details

  • Cell-permeable SOD/Catalase mimetic
  • CAS Number:
  • Purity: > 96%
  • Soluble in water
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    MnTMPyP Pentachloride, SOD/Catalase mimetic

  • Description

    Cell-permeable SOD/Catalase mimetic

  • Biological description

    Cell-permeable SOD/Catalase mimetic. Catalyzes dismutation of superoxide. Peroxynitrite inhibitor. Oxidative stress inhibitor. Active in vitro and in vivo.

  • Purity

    > 96%

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)-21H,23H-porphyrin manganese(III) pentachloride

  • Molecular weight

    909.01

  • Molecular formula

    Mn(C44H36N8)Cl5

  • PubChem identifier

    4233

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in water

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[N+]1=CC=C(C=C1)C2=C3C=CC(=C(C4=NC(=C(C5=CC=C([N-]5)C(=C6C=CC2=N6)C7= CC=[N+](C=C7)C)C8=CC=[N+](C=C8)C)C=C4)C9=CC=[N+](C=C9)C)[N-]3.[Mn+3]

  • Source

    Synthetic

  • Research areas

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (1)

Publishing research using ab142212? Please let us know so that we can cite the reference in this datasheet.

ab142212 has been referenced in 1 publication.

  • Pritchard R  et al. Celecoxib inhibits mitochondrial O2 consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway. Biochem Pharmacol 154:318-334 (2018). PubMed: 29800556

Customer reviews and Q&As

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Question

How should this be reconsituted and stored for maximum stability?

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Answer

I am sorry to report I was not able to find any stability data for MnTMPyP. The paper at the following link discusses stability under assay conditions but not storage. It appears to be the earliest reference for this compound.


http://www.jbc.org/content/269/38/23471.full.pdf

J Biol Chem. 1994 Sep 23;269(38):23471-6.

Other vendors specify a limit of 3 months at -20C after reconstitution in water as a guideline for storage.

It will go into solution in DMSO but it is not clear that it will be any more stable in DMSO than in water. The study in the following reference used a DMSO solution, for example, figure 4.

http://www.ncbi.nlm.nih.gov/pubmed/?term=9832148
J Neurochem. 1998 Dec;71(6):2497-504.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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