Overview

  • Product name

    Anti-Mob1A antibody - C-terminal
    See all Mob1A primary antibodies
  • Description

    Rabbit polyclonal to Mob1A - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Mob1A (C terminal). NP_060691
    Database link: Q9H8S9

  • Positive control

    • Human liver cancer tissue. A375, K562, mouse liver tissue, Raji, Jurkat and HeLa cell lysate.
  • General notes

     This product was previously labelled as MOBK1B

     

Properties

Applications

Our Abpromise guarantee covers the use of ab198916 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 25 kDa.
IHC-P 1/25 - 1/100.

Target

  • Function

    Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.
  • Tissue specificity

    Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.
  • Sequence similarities

    Belongs to the MOB1/phocein family.
  • Information by UniProt
  • Database links

  • Alternative names

    • B1, Mps One Binder kinase activator like 1B (yeast) antibody
    • C2orf6 antibody
    • Chromosome 2 open reading frame 6 antibody
    • FLJ10788 antibody
    • FLJ11595 antibody
    • MATS1 antibody
    • MOB kinase activator 1A antibody
    • MOB1 antibody
    • Mob1 alpha antibody
    • Mob1 homolog 1B antibody
    • MOB1 Mps One Binder homolog A antibody
    • MOB1 Mps One Binder kinase activator like 1B antibody
    • Mob1A antibody
    • MOB4B antibody
    • Mob4B protein antibody
    • MOBK1B antibody
    • Mobkl1b antibody
    • MOL1B_HUMAN antibody
    • Mps one binder kinase activator like 1B antibody
    • Mps one binder kinase activator-like 1B antibody
    • Protein Mob4B antibody
    see all

Images

  • All lanes : Anti-Mob1A antibody - C-terminal (ab198916) at 1/200 dilution

    Lane 1 : A375 cell lysate
    Lane 2 : K562 cell lysate
    Lane 3 : Mouse liver tissue lysate
    Lane 4 : Raji cell lysate
    Lane 5 : Jurkat cell lysate
    Lane 6 : HeLa cell lysate

    Lysates/proteins at 40 µg per lane.

    Predicted band size: 25 kDa


    Exposure time: 10 seconds


    Gel: 10% SDS-PAGE

  • Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling Mob1A with ab198916 at a 1/20 dilution.

References

ab198916 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab198916.
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