Key features and details
- Rabbit polyclonal to MOCS1
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Product nameAnti-MOCS1 antibody
See all MOCS1 primary antibodies
DescriptionRabbit polyclonal to MOCS1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse
Predicted to work with: Cow, Human
Recombinant fragment corresponding to Human MOCS1 aa 90-360.
EEGVPLTPKANLLTTEEILTLARLFVKEGIDKIRLTGGEPLIRPDVVDIV AQLQRLEGLRTIGVTTNGINLARLLPQLQKAGLSAINISLDTLVPAKFEF IVRRKGFHKVMEGIHKAIELGYNPVKVNCVVMRGLNEDELLDFAALTEGL PLDVRFIEYMPFDGNKWNFKKMVSYKEMLDTVRQQWPELEKVPEEESSTA KAFKIPGFQGQISFITSMSEHFCGTCNRLRITADGNLKVCLFGNSEVSLR DHLRAGASEQELLRIIGAAVG
Database link: Q9NZB8
- WB: Mouse heart tissue lysate.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab230275 in the following tested applications.
|WB||1/1000 - 1/5000. Detects a band of approximately 70 kDa (predicted molecular weight: 70, 40, 40, 31, 70, 58 kDa).|
FunctionIsoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of a guanosine derivative to precursor Z during molybdenum cofactor biosynthesis.
Tissue specificityIsoform MOCS1A and isoform 2 are widely expressed.
PathwayCofactor biosynthesis; molybdopterin biosynthesis.
Involvement in diseaseDefects in MOCS1 are the cause of molybdenum cofactor deficiency type A (MOCOD type A) [MIM:252150]; an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.
Sequence similaritiesIn the C-terminal section; belongs to the moaC family.
In the N-terminal section; belongs to the moaA/nifB/pqqE family.
modificationsIsoform MOCS1A, isoform 2 and isoform 3 are probably thiocarboxylated at their C-terminus. Thiocarboxylation probably plays a central role in molybdenum cofactor biosynthesis, since mutagenesis of the last 2 Gly residues of isoform MOCS1A abolishes the catalytic activity of the enzyme. Thiocarboxylation is absent in isoform MOCS1B, which lacks the C-terminal Gly residue.
- Information by UniProt
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ab230275 has not yet been referenced specifically in any publications.