Description

  • Product name

    Modified EIF2S peptide
  • Animal free

    No
  • Nature

    Synthetic
    • Sequence

      Modified-CILLSELSRRRIR
    • Additional sequence information

      The peptide is derived from human EIF2S1; aa46-57.

Associated products

Specifications

Our Abpromise guarantee covers the use of ab204868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    Functional Studies

  • Form

    Liquid
  • Additional notes

    The Modified EIF2S peptide sequence (Modified-CILLSELSRRRIR) is derived from human EIF2S1 (46-57) and is suitable for use as the substrate for EIF2AK kinase family and MNK1.

     

    ab204868 (Modified EIF2S peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab125635 (Active human MNK1 full length protein)

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • EIF-2
    • eIF-2-alpha
    • eIF-2-beta
    • eIF-2-gamma X
    • eIF-2A
    • eIF-2alpha
    • eIF-2gA
    • eIF-2gX
    • EIF2
    • EIF2A
    • EIF2B
    • EIF2beta
    • EIF2G
    • EIF2gamma
    • EIF2S1
    • EIF2S2
    • EIF2S3
    • Eukaryotic translation initiation factor 2 subunit 1
    • Eukaryotic translation initiation factor 2 subunit 2
    • Eukaryotic translation initiation factor 2 subunit 3
    • Eukaryotic translation initiation factor 2 subunit alpha
    • Eukaryotic translation initiation factor 2 subunit beta
    • Eukaryotic translation initiation factor 2 subunit gamma X
    • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
    • eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
    • eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
    • PPP1R67
    see all
  • Relevance

    Eukaryotic translation initiation factor 2 (eIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Post-translational modification: Substrate for at least 4 kinases: EIF2AK3/PERK, GCN2, HRI and PKR. Phosphorylation stabilizes the eIF-2/GDP/eIF-2B complex and prevents GDP/GTP exchange reaction, thus impairing the recycling of eIF-2 between successive rounds of initiation and leading to global inhibition of translation. In case of infection by vaccinia virus or rotavirus A, eIF2S1 phosphorylation state is modulated. Subunit structure: Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interaction with METAP2 protects EIF2S1 from inhibitory phosphorylation. Interacts with ABCF1 isoform 2. Associates with ribosomes.

References

ab204868 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab204868.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up