Overview

  • Product name

    Molsidomine, Guanylate cyclase activator
  • Description

    Long-lasting NO donor. Guanylate cyclase activator.
  • Biological description

    Long-lasting NO donor and vasodilator that requires hepatic metabolism for activity.
    Activates guanylate cyclase.
  • Purity

    > 98%
  • CAS Number

    25717-80-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1E)-1-Ethoxy-N-(3-morpholin-4-yloxadiazol-3-ium-5-yl)methanimidate
  • Molecular weight

    242.23
  • Molecular formula

    C9H14N4O4
  • PubChem identifier

    5353788
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 50 mM, in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCOC(=NC1=C[N+](=NO1)N2CCOCC2)[O-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kovanecz I  et al. Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damage. J Sex Med 9:2814-26 (2012). Read more (PubMed: 22974131) »
  • Hernández-Melesio MA  et al. Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin. Neurosci Lett 491:133-7 (2011). Read more (PubMed: 21237248) »
  • Bongartz LG  et al. The nitric oxide donor molsidomine rescues cardiac function in rats with chronic kidney disease and cardiac dysfunction. Am J Physiol Heart Circ Physiol 299:H2037-45 (2010). Read more (PubMed: 20852057) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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