Overview

  • Product name

    Mometasone furoate, synthetic corticosteroid
  • Description

    Potent synthetic corticosteroid
  • Biological description

    Potent synthetic corticosteroid. Prodrug of mometasone. Stabilises cell membranes. Inhibits efflux transporters. Shows anti-inflammatory and antiallergenic effects in vivo.
  • CAS Number

    83919-23-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(8S,9R,10S,11S,13S,14S,16R,17R)-9-Chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]furan-2-carboxylate
  • Molecular weight

    521.43
  • Molecular formula

    C27H30Cl2O6
  • PubChem identifier

    441336
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C(C=C2[C@](C=1)([C@]3([C@@](CC2)([C@]4([C@](C[C@H]3O)([C@@]([C@@H](C4)C)(C(CCl)=O)OC(=O)C5=CC=CO5)C)[H])[H])Cl)C)=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Raposo S  et al. Mometasone furoate-loaded cold processed oil-in-water emulsions: in vitro and in vivo studies. Drug Deliv : (2014). Read more (PubMed: 24559480) »
  • Chen J  et al. Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol Appl Pharmacol 272:408-13 (2013). Read more (PubMed: 23800689) »
  • Cooray HC  et al. Modulation of p-glycoprotein and breast cancer resistance protein by some prescribed corticosteroids. Eur J Pharmacol 531:25-33 (2006). Read more (PubMed: 16442095) »

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