Moniliformin, pyruvate dehydrogenase inhibitor. (ab143525)

Overview

  • Product name

    Moniliformin, pyruvate dehydrogenase inhibitor.
  • Description

    Mycotoxin. Competitive pyruvate dehydrogenase inhibitor.
  • Biological description

    Mycotoxin. Competitive pyruvate dehydrogenase inhibitor. Shows cytotoxic effects (IC20 = 4 mM). Reduces muscle contractility. Shows cardiotoxic effects and induces ventricular hypertrophy in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    31876-38-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Behm C  et al. Cytotoxic potency of mycotoxins in cultures of V79 lung fibroblast cells. J Toxicol Environ Health A 75:1226-31 (2012). Read more (PubMed: 22994576) »
  • Kamyar MR  et al. Effects of moniliformin in presence of cyclohexadepsipeptides on isolated mammalian tissue and cells. Toxicol In Vitro 20:1284-91 (2006). Read more (PubMed: 16621435) »
  • Zhao D  et al. Ultrastructural study of moniliformin induced lesions of myocardium in rats and mice. Biomed Environ Sci 6:37-44 (1993). Read more (PubMed: 8476531) »

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