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Neuroscience Neurotransmitter Biogenic Amines Dopamine
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Anti-Monoamine Oxidase B/MAOB antibody (ab175136)

  • Datasheet
  • SDS
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Immunocytochemistry/ Immunofluorescence - Anti-Monoamine Oxidase B/MAOB antibody (ab175136)
  • Western blot - Anti-Monoamine Oxidase B/MAOB antibody (ab175136)

Key features and details

  • Rabbit polyclonal to Monoamine Oxidase B/MAOB
  • Suitable for: ICC/IF, WB
  • Reacts with: Human
  • Isotype: IgG

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Overview

  • Product name

    Anti-Monoamine Oxidase B/MAOB antibody
    See all Monoamine Oxidase B/MAOB primary antibodies
  • Description

    Rabbit polyclonal to Monoamine Oxidase B/MAOB
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human Monoamine Oxidase B/MAOB.
    Database link: P27338

  • General notes

     This product was previously labelled as Monoamine Oxidase B

     

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmitter
    • Biogenic Amines
    • Dopamine
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Parkinson's disease
    • Other
    • Signal Transduction
    • Metabolism
    • Amino Acids
    • Signal Transduction
    • Metabolism
    • Drug metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Amino acid metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Drug metabolism
    • Metabolism
    • Types of disease
    • Neurodegenerative disease

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human Monoamine Oxidase B/MAOB protein (ab82944)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab175136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
Use at an assay dependent concentration.
WB
1/500 - 1/2000. Predicted molecular weight: 59 kDa.
Notes
ICC/IF
Use at an assay dependent concentration.
WB
1/500 - 1/2000. Predicted molecular weight: 59 kDa.

Target

  • Function

    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
  • Sequence similarities

    Belongs to the flavin monoamine oxidase family.
  • Cellular localization

    Mitochondrion outer membrane.
  • Target information above from: UniProt accession P27338 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 4129 Human
    • Omim: 309860 Human
    • SwissProt: P27338 Human
    • Unigene: 654473 Human
    • Alternative names

      • Adrenalin oxidase antibody
      • Amine oxidase (flavin containing) antibody
      • Amine oxidase [flavin-containing] B antibody
      • AOFB_HUMAN antibody
      • MAO, brain antibody
      • MAO, platelet antibody
      • MAO-B antibody
      • MAOB antibody
      • MGC26382 antibody
      • Monoamine oxidase B antibody
      • Monoamine oxidase type B antibody
      • OTTHUMP00000023166 antibody
      • Tyramine oxidase antibody
      see all

    Images

    • Immunocytochemistry/ Immunofluorescence - Anti-Monoamine Oxidase B/MAOB antibody (ab175136)
      Immunocytochemistry/ Immunofluorescence - Anti-Monoamine Oxidase B/MAOB antibody (ab175136)
      Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab175136. Blue DAPI for nuclear staining.
    • Western blot - Anti-Monoamine Oxidase B/MAOB antibody (ab175136)
      Western blot - Anti-Monoamine Oxidase B/MAOB antibody (ab175136)
      All lanes : Anti-Monoamine Oxidase B/MAOB antibody (ab175136) at 1/500 dilution

      Lane 1 : Human fetal kidney cell extract
      Lane 2 : Human platelet cell extract
      Lane 3 : Human fetal brain cell extract

      Predicted band size: 59 kDa

    Protocols

    • Western blot protocols
    • Immunocytochemistry & immunofluorescence protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (2)

    Publishing research using ab175136? Please let us know so that we can cite the reference in this datasheet.

    ab175136 has been referenced in 2 publications.

    • Kakinuma S  et al. Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson's disease. eNeurologicalSci 19:100239 (2020). PubMed: 32346620
    • Chumarina M  et al. Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene. Acta Neuropathol Commun 7:208 (2019). PubMed: 31843010

    Customer reviews and Q&As

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