Overview

  • Product name

    Monobenzone (Benoquin), induces depigmentation
  • Description

    Induces loss of epidermal melanocytes in vivo
  • Biological description

    Induces loss of epidermal melanocytes in vivo. Induces T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy. Skin depigmentation and immunotherapy agent. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    103-16-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Zhu Y  et al. A mouse model of vitiligo induced by monobenzone. Exp Dermatol 22:499-501 (2013). Read more (PubMed: 23800067) »
  • van den Boorn JG  et al. Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy. J Invest Dermatol 131:1240-51 (2011). Read more (PubMed: 21326294) »
  • Manini P  et al. A reactive ortho-quinone generated by tyrosinase-catalyzed oxidation of the skin depigmenting agent monobenzone: self-coupling and thiol-conjugation reactions and possible implications for melanocyte toxicity. Chem Res Toxicol 22:1398-405 (2009). Read more (PubMed: 19610592) »

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