Anti-MCT1/Monocarboxylic acid transporter 1 antibody (ab93048)
Key features and details
- Rabbit polyclonal to MCT1/Monocarboxylic acid transporter 1
- Suitable for: ELISA
- Reacts with: Mouse
- Isotype: IgG
Overview
-
Product name
Anti-MCT1/Monocarboxylic acid transporter 1 antibody
See all MCT1/Monocarboxylic acid transporter 1 primary antibodies -
Description
Rabbit polyclonal to MCT1/Monocarboxylic acid transporter 1 -
Host species
Rabbit -
Tested applications
Suitable for: ELISAmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Purification notes
Purity >90% -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab93048 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ELISA |
Use at an assay dependent concentration.
|
Notes |
---|
ELISA
Use at an assay dependent concentration. |
Target
-
Function
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. -
Tissue specificity
Widely expressed in normal and in cancer cells. -
Involvement in disease
Symptomatic deficiency in lactate transport
Familial hyperinsulinemic hypoglycemia 7 -
Sequence similarities
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. -
Cellular localization
Cell membrane. - Information by UniProt
-
Database links
- Entrez Gene: 20501 Mouse
- Entrez Gene: 25027 Rat
- SwissProt: P53986 Mouse
- SwissProt: P53987 Rat
- Unigene: 9086 Mouse
- Unigene: 6085 Rat
-
Alternative names
- FLJ36745 antibody
- HHF7 antibody
- MCT 1 antibody
see all
Protocols
Datasheets and documents
-
SDS download
-
Datasheet download
References (5)
ab93048 has been referenced in 5 publications.
- Buyse C et al. Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification. Metabolites 12:N/A (2022). PubMed: 35736489
- D'Adamo P et al. Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse. Metabolism 116:154463 (2021). PubMed: 33309713
- Benyahia Z et al. In Vitro and In Vivo Characterization of MCT1 Inhibitor AZD3965 Confirms Preclinical Safety Compatible with Breast Cancer Treatment. Cancers (Basel) 13:N/A (2021). PubMed: 33540599
- Wang D et al. Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs. Arthritis Res Ther 23:145 (2021). PubMed: 34020698
- Zhao D et al. Altered expression of lactate dehydrogenase and monocarboxylate transporter involved in lactate metabolism in broiler wooden breast. Poult Sci 99:11-20 (2020). PubMed: 32416791