Anti-Monocyte + Macrophage antibody [MOMA-2] (ab33451)
Key features and details
- Rat monoclonal [MOMA-2] to Monocyte + Macrophage
- Suitable for: IHC-Fr, IHC-P, IHC-FoFr, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2b
Overview
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Product name
Anti-Monocyte + Macrophage antibody [MOMA-2] -
Description
Rat monoclonal [MOMA-2] to Monocyte + Macrophage -
Host species
Rat -
Specificity
This antibody recognises an intracellular antigen of mouse macrophages and monocytes. It reacts strongly with macrophages in lymphoid organs in all mouse strains tested. Staining may also be seen on the epithelium of mucosa.
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Tested applications
Suitable for: IHC-Fr, IHC-P, IHC-FoFr, Flow Cytmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Tissue, cells or virus corresponding to Mouse Monocyte + Macrophage. Mouse lymph node stroma.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
Preservative: 0.09% Sodium azide -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
MOMA-2 -
Isotype
IgG2b -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab33451 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-Fr | (2) |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration. PubMed: 24449804
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IHC-FoFr | (1) |
Use at an assay dependent concentration.
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Flow Cyt |
Use at an assay dependent concentration.
Membrane permeabilisation is required for this application. ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Notes |
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IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. PubMed: 24449804 |
IHC-FoFr
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. Membrane permeabilisation is required for this application. ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Target
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Relevance
Monocyte and macrophage are white blood cells that roam the body tissues engulfing foreign organisms. A monocyte is a leukocyte, part of the human body's immune system that protects against blood-borne pathogens and moves quickly (aprox. 8-12 hours) to sites of infection in the tissues. Monocytes are usually identified in stained smears by their large bi-lobed nucleus. Macrophages are cells within the tissues that originate from specific white blood cells called monocytes. Monocytes and macrophages are phagocytes, acting in both nonspecific defense (or innate immunity) as well as specific defense (or cell-mediated immunity) of vertebrate animals. Their role is to phagocytize (engulf and then digest) cellular debris and pathogens either as stationary or mobile cells, and to stimulate lymphocytes and other immune cells to respond to the pathogen. -
Alternative names
- Macrophages antibody
- Monocytes antibody
Datasheets and documents
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SDS download
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Datasheet download
References (92)
ab33451 has been referenced in 92 publications.
- Li Z et al. Astragali Radix-Coptis Rhizoma Herb Pair Attenuates Atherosclerosis in ApoE-/- Mice by Regulating the M1/M2 and Th1/Th2 Immune Balance and Activating the STAT6 Signaling Pathway. Evid Based Complement Alternat Med 2022:7421265 (2022). PubMed: 35178108
- Sun S et al. Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis. Front Cell Dev Biol 10:827714 (2022). PubMed: 35281076
- Qi Y et al. Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora. Front Pharmacol 13:805266 (2022). PubMed: 35431939
- Iwamoto M et al. The sodium-glucose co-transporter 2 inhibitor tofogliflozin suppresses atherosclerosis through glucose lowering in ApoE-deficient mice with streptozotocin-induced diabetes. Pharmacol Res Perspect 10:e00971 (2022). PubMed: 35707828
- Lin CW et al. Restoring Prohealing/Remodeling-Associated M2a/c Macrophages Using ON101 Accelerates Diabetic Wound Healing. JID Innov 2:100138 (2022). PubMed: 36017415