Monosodium urate (PBS solution), NLRP3/NALP3 inflammasome activator (ab144306)

Overview

  • Product name

    Monosodium urate (PBS solution), NLRP3/NALP3 inflammasome activator
  • Description

    NLRP3/NALP3 inflammasome activator
  • CAS Number

    1198-77-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,8-Dioxo-3,7,8,9-tetrahydro-2H-purin-6-olate sodium salt
  • Molecular weight

    190.09
  • Molecular formula

    C5H3N4NaO3
  • PubChem identifier

    23697816
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C1NC=2NC(=O)N=C(O[Na])C=2N1
  • Source

    Synthetic

References

This product has been referenced in:

  • Giamarellos-Bourboulis EJ  et al. Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1 beta by mononuclear cells through a caspase 1-mediated process. Ann Rheum Dis 68:273-8 (2009). Read more (PubMed: 18390571) »
  • Martin WJ  et al. Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. Arthritis Rheum 60:281-9 (2009). Read more (PubMed: 19116939) »
  • Martinon F  et al. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237-41 (2006). Read more (PubMed: 16407889) »

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