Monosodium urate, Pro-inflammatory agent (ab144305)

Overview

  • Product name

    Monosodium urate, Pro-inflammatory agent
  • Description

    Pro-inflammatory agent
  • Biological description

    Pro-inflammatory agent. induces Syk and PI3K activation. Induces phagocytosis, and IL-1β production. Activates TRPV1 and induces mast cell degranulation. Induces inflammation and algesic effects in vivo.
  • CAS Number

    1198-77-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,8-Dioxo-3,7,8,9-tetrahydro-2H-purin-6-olate sodium salt
  • Molecular weight

    190.09
  • Molecular formula

    C5H3N4NaO3
  • PubChem identifier

    23697816
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 N NaOH to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C1NC=2NC(=O)N=C(O[Na])C=2N1
  • Source

    Synthetic

References

This product has been referenced in:

  • Silva CR  et al. The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents. Ann Rheum Dis : (2014). Read more (PubMed: 25344431) »
  • Hoffmeister C  et al. Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats. Pain 152:1777-88 (2011). Read more (PubMed: 21550723) »
  • Shi Y  et al. Monosodium urate crystals in inflammation and immunity. Immunol Rev 233:203-17 (2010). Read more (PubMed: 20193001) »

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