Overview

  • Product name

  • Description

    Rabbit polyclonal to MORC3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human MORC3 aa 634-663 (internal sequence) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q14149

  • Positive control

    • WB: HL-60 and U-87 MG cell lysates. IHC-P: Human placenta, pancreas and tonsil tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab230878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100.
WB 1/1000. Predicted molecular weight: 107 kDa.

Target

  • Function

    Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).
  • Tissue specificity

    Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.
  • Sequence similarities

    Contains 1 CW-type zinc finger.
  • Post-translational
    modifications

    Sumoylation is involved in interaction with PML and localization to PML nuclear bodies.
  • Cellular localization

    Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.
  • Information by UniProt
  • Database links

  • Alternative names

    • KIAA0136 antibody
    • Microrchidia 3 antibody
    • MORC family CW type zinc finger 3 antibody
    • MORC family CW type zinc finger protein 3 antibody
    • MORC family CW-type zinc finger protein 3 antibody
    • MORC3 antibody
    • MORC3_HUMAN antibody
    • Nuclear matrix protein 2 antibody
    • Nuclear matrix protein NXP2 antibody
    • NXP2 antibody
    • ZCW5 antibody
    • ZCWCC3 antibody
    • Zinc finger CW type coiled coil domain 3 antibody
    • Zinc finger CW type coiled coil domain protein 3 antibody
    • Zinc finger CW type with coiled coil domain 3 antibody
    • Zinc finger CW-type coiled-coil domain protein 3 antibody
    see all

Images

  • All lanes : Anti-MORC3 antibody (ab230878) at 1/1000 dilution

    Lane 1 : HL-60 (Human promyelocytic leukemia cell line) cell lysate
    Lane 2 : U-87 MG (Human glioblastoma-astrocytoma epithelial cell line) cell lysate

    Lysates/proteins at 35 µg per lane.

    Predicted band size: 107 kDa

  • Formalin-fixed, paraffin-embedded human pancreas tissue stained for MORC3 using ab230878 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human tonsil tissue stained for MORC3 using ab230878 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human placenta tissue stained for MORC3 using ab230878 at 1/100 dilution in immunohistochemical analysis.

References

ab230878 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab230878.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up