Key features and details
- Rabbit polyclonal to MORC3
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MORC3 antibody
See all MORC3 primary antibodies
DescriptionRabbit polyclonal to MORC3
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Synthetic peptide within Human MORC3 aa 634-663 (internal sequence) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
Database link: Q14149
- WB: HL-60 and U-87 MG cell lysates. IHC-P: Human placenta, pancreas and tonsil tissues.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab230878 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Predicted molecular weight: 107 kDa.|
FunctionNuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).
Tissue specificityExpressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.
Sequence similaritiesContains 1 CW-type zinc finger.
modificationsSumoylation is involved in interaction with PML and localization to PML nuclear bodies.
Cellular localizationNucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.
- Information by UniProt
- KIAA0136 antibody
- Microrchidia 3 antibody
- MORC family CW type zinc finger 3 antibody
All lanes : Anti-MORC3 antibody (ab230878) at 1/1000 dilution
Lane 1 : HL-60 (Human promyelocytic leukemia cell line) cell lysate
Lane 2 : U-87 MG (Human glioblastoma-astrocytoma epithelial cell line) cell lysate
Lysates/proteins at 35 µg per lane.
Predicted band size: 107 kDa
Formalin-fixed, paraffin-embedded human pancreas tissue stained for MORC3 using ab230878 at 1/100 dilution in immunohistochemical analysis.
Formalin-fixed, paraffin-embedded human tonsil tissue stained for MORC3 using ab230878 at 1/100 dilution in immunohistochemical analysis.
Formalin-fixed, paraffin-embedded human placenta tissue stained for MORC3 using ab230878 at 1/100 dilution in immunohistochemical analysis.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab230878 has not yet been referenced specifically in any publications.