• Product name

    Anti-Morg1 antibody - Aminoterminal end
  • Description

    Rabbit polyclonal to Morg1 - Aminoterminal end
  • Host species

  • Tested applications

    Suitable for: ICC/IF, WB, IHC-P, ICCmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to a sequence near the N-terminus of human Morg1, identical to the related mouse and rat sequence.

  • Positive control

    • Mammary cancer tissue



Our Abpromise guarantee covers the use of ab65870 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 5 µg/ml.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa.
IHC-P Use a concentration of 0.5 - 1 µg/ml.
ICC Use at an assay dependent concentration.


  • Function

    Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.
  • Sequence similarities

    Belongs to the WD repeat MORG1 family.
    Contains 7 WD repeats.
  • Cellular localization

    Cytoplasm. Nucleus. Predominantly cytoplasmic (By similarity). Partially nuclear.
  • Information by UniProt
  • Database links

  • Alternative names

    • MAPK organizer 1 antibody
    • MGC4238 antibody
    • Mitogen activated protein kinase organizer 1 antibody
    • Mitogen-activated protein kinase organizer 1 antibody
    • MORG 1 antibody
    • WD repeat domain-containing protein 83 antibody
    • wdr83 antibody
    • WDR83_HUMAN antibody
    see all


  • This image shows human mammary cancer tissue stained with ab65870 at 1µg/ml. Cytoplasmic staining of Morg1, using DAB.
  • Anti-Morg1 antibody - Aminoterminal end (ab65870) at 1 µg/ml + rat brain tissue lysate

    Predicted band size: 34 kDa
    Observed band size: 34 kDa

  • ICC/IF image of ab65870 stained HepG2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab65870, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.


This product has been referenced in:

  • Su WY  et al. Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer. Cell Res : (2012). ICC/IF . Read more (PubMed: 22491477) »
See 1 Publication for this product

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