Mosapride citrate, 5-HT4 agonist (ab142992)

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Overview

  • Product name

    Mosapride citrate, 5-HT4 agonist

  • Description

    Potent and selective 5-HT4 agonist

  • Biological description

    Potent and selective 5-HT4 agonist. Enhances electrically-evoked ileum contractions (EC50 = 73 nM). Shows low affinity for colon than for the rest of the GI tract. Accelerates gastric emptying and promotes gastrointestinal neurogenesis in vivo. Orally active.

  • Purity

    > 99%

  • CAS Number

    112885-42-4

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide citrate

  • Molecular weight

    614.02

  • Molecular formula

    C21H25ClFN3O3.C6H8O7

  • PubChem identifier

    119583

  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble inDMSO to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=C(C=C(C(=C1)C(NCC2OCCN(C2)CC3=CC=C(C=C3)F)=O)OCC)N)Cl.OC(CC(CC(O)=O)(C(=O)O)O)=O

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Takaki M  et al. The 5-hydroxytryptamine 4 Receptor Agonist-induced Actions and Enteric Neurogenesis in the Gut. J Neurogastroenterol Motil 20:17-30 (2014). Read more (PubMed: 24466442) »
  • Zhou J  et al. Human prokinetic drugs promote gastrointestinal motility in zebrafish. Neurogastroenterol Motil 26:589-595 (2014). Read more (PubMed: 24533865) »
  • Mine Y  et al. Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J Pharmacol Exp Ther 283:1000-8 (1997). Read more (PubMed: 9399969) »

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