Overview

  • Product name

    MoTP, platelet activating factor receptor antagonist
  • Description

    Specific platelet activating factor receptor antagonist
  • Alternative names

    • MoTP
  • Biological description

    Specific platelet activating factor (PAF)-receptor antagonist (IC50 = 0.28 μM). PLC inhibitor (IC50 = 1.05 μM). PAF-induced hypotension inhibitor. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    57055-82-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-(4-Morpholin-4-ylbutylsulfanyl)phenol
  • Molecular weight

    267.39
  • Molecular formula

    C14H21NO2S
  • PubChem identifier

    107681
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc1ccc(cc1)SCCCCN2CCOCC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Morrison WJ & Shukla SD Antagonism of platelet activating factor receptor binding and stimulated phosphoinositide-specific phospholipase C in rabbit platelets. J Pharmacol Exp Ther 250:831-5 (1989). Read more (PubMed: 2550620) »
  • Kobayashi T  et al. Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs. Xenobiotica 18:49-59 (1988). Read more (PubMed: 3354232) »
  • Terashita Z  et al. Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet. Biochem Pharmacol 34:1491-5 (1985). Read more (PubMed: 2986648) »
  • Terashita Z  et al. CV-3988 - a specific antagonist of platelet activating factor (PAF). Life Sci 32:1975-82 (1983). Read more (PubMed: 6403793) »

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