Mouse FLIP peptide (ab8456)
- Datasheet
- References
- Protocols
Overview
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Product nameMouse FLIP peptide
See all FLIP proteins and peptides
Description
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NatureSynthetic
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Amino Acid Sequence
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SpeciesMouse
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SequenceDKVYAWNSGVSSKEKYS Amino acids 449 to 465 of human mFLIP (1,2)
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Amino acids449 to 465
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Associated products
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Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab8456 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Blocking - Blocking peptide for Anti-FLIP antibody (ab8422)
Western blot
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FormLiquid
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
General Info
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Alternative names
- c FLIP
- c FLIPL
- c FLIPR
see all -
FunctionApoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
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Tissue specificityWidely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
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Sequence similaritiesBelongs to the peptidase C14A family.
Contains 2 DED (death effector) domains. -
DomainThe caspase domain lacks the active sites residues involved in catalysis.
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Post-translational
modificationsProteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12. - Information by UniProt
Datasheets and documents
References
ab8456 has not yet been referenced specifically in any publications.
