• Product name
    Mouse Ionotropic Glutamate receptor 2 peptide


  • Nature
  • Amino Acid Sequence
    • Species

Associated products


Our Abpromise guarantee covers the use of ab25708 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Ionotropic Glutamate receptor 2 antibody (ab20673)

  • Form
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • AMPA 2
    • AMPA selective glutamate receptor 2
    • AMPA-selective glutamate receptor 2
    • AMPA2
    • GluA2
    • GLUR 2
    • GLUR B
    • GluR K2
    • GluR-2
    • GluR-B
    • GluR-K2
    • GLUR2
    • GLURB
    • Glutamate receptor 2
    • Glutamate receptor ionotropic
    • Glutamate receptor ionotropic AMPA 2
    • Gria2
    • HBGR2
    see all
  • Function
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
  • Sequence similarities
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
  • Post-translational
    Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • Cellular localization
    Cell membrane. Endoplasmic reticulum membrane. Cell junction > synapse > postsynaptic cell membrane. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.
  • Information by UniProt


ab25708 has not yet been referenced specifically in any publications.

Customer reviews and Q&As


Thank you for contacting us.

The ab20673has not been tested on human samples yet, but is thought to be working as the homology is high. Please let me know if you would like to test this on your own asI could offer you our AbTrial discount.

Our peptides are usually designed to block the antibody. This way you can asses how specific an antibody works. We haven't performed any functional studies with it, and as it is only a very short peptide of 14AA, it is quite unlikely that it will block the channel. Unfortunately, we do not have another peptide or protein in our catalog which is suitable for this purpose.

We have a few antibodies which have already tested on human samples in IHC:

https://www.abcam.com/index.html?datasheet=87605 (or use the following: https://www.abcam.com/index.html?datasheet=87605).

https://www.abcam.com/index.html?datasheet=87606 (or use the following: https://www.abcam.com/index.html?datasheet=87606).

https://www.abcam.com/index.html?datasheet=101887 (or use the following: https://www.abcam.com/index.html?datasheet=101887).

https://www.abcam.com/index.html?datasheet=106515 (or use the following: https://www.abcam.com/index.html?datasheet=106515).

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Use our products? Submit an Abreview. Earn rewards!

Read More


Sign up