Mouse IRS1 (phospho Y608) peptide (ab204093)
- Datasheet
- References
- Protocols
Description
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Product name
Mouse IRS1 (phospho Y608) peptide
See all IRS1 proteins and peptides -
Accession
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Animal free
No -
Nature
Synthetic -
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Species
Mouse -
Sequence
KKHTDDGYMPMSPGVA -
Predicted molecular weight
2 kDa -
Amino acids
603 to 616 -
Modifications
phospho Y608
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Specifications
Our Abpromise guarantee covers the use of ab204093 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
HPLC
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Form
Lyophilised -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Store at -20°C. Avoid freeze / thaw cycle.
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ReconstitutionReconstitute in 20mM Tris-HCl, pH7.5 to a final concentration on 1 mg/mL.
General Info
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Alternative names
- HIRS 1
- HIRS1
- Insulin receptor substrate 1
see all -
Function
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. -
Involvement in disease
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. -
Sequence similarities
Contains 1 IRS-type PTB domain.
Contains 1 PH domain. -
Post-translational
modificationsSerine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding. - Information by UniProt
Datasheets and documents
References
ab204093 has not yet been referenced specifically in any publications.
