Mouse IRS1 (phospho Y608) peptide (ab204093)
Key features and details
- Suitable for: HPLC
Description
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Product name
Mouse IRS1 (phospho Y608) peptide
See all IRS1 proteins and peptides -
Accession
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Animal free
No -
Nature
Synthetic -
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Species
Mouse -
Sequence
KKHTDDGYMPMSPGVA -
Predicted molecular weight
2 kDa -
Amino acids
603 to 616 -
Modifications
phospho Y608
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Specifications
Our Abpromise guarantee covers the use of ab204093 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
HPLC
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Store at -20°C. Avoid freeze / thaw cycle.
pH: 7.5
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ReconstitutionReconstitute in 20mM Tris-HCl, pH7.5 to a final concentration on 1 mg/mL.
General Info
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Alternative names
- HIRS 1
- HIRS1
- Insulin receptor substrate 1
see all -
Function
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. -
Involvement in disease
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. -
Sequence similarities
Contains 1 IRS-type PTB domain.
Contains 1 PH domain. -
Post-translational
modificationsSerine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab204093 has not yet been referenced specifically in any publications.