Mouse IRS1 (phospho Y608) peptide (ab204093)

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Key features and details

  • Suitable for: HPLC

Description

  • Product name

    Mouse IRS1 (phospho Y608) peptide
    See all IRS1 proteins and peptides

  • Accession

    P35569

  • Animal free

    No

  • Nature

    Synthetic

    • Species

      Mouse

    • Sequence

      KKHTDDGYMPMSPGVA

    • Predicted molecular weight

      2 kDa

    • Amino acids

      603 to 616

    • Modifications

      phospho Y608

Specifications

Our Abpromise guarantee covers the use of ab204093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

  • Form

    Lyophilized
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -20°C. Avoid freeze / thaw cycle.

    pH: 7.5

  • Reconstitution
    Reconstitute in 20mM Tris-HCl, pH7.5 to a final concentration on 1 mg/mL.

General Info

  • Alternative names

    • HIRS 1
    • HIRS1
    • Insulin receptor substrate 1
    • IRS 1
    • IRS-1
    • IRS1
    • IRS1_HUMAN
    • OTTHUMP00000164234
    see all

  • Function

    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

  • Involvement in disease

    Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].

  • Sequence similarities

    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.

  • Post-translational
    modifications

    Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab204093? Please let us know so that we can cite the reference in this datasheet.

ab204093 has not yet been referenced specifically in any publications.

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