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RecombinantRabMAb

Mouse LOX1 Antibody Pair - BSA and Azide free (ab241730)

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Sandwich ELISA - Mouse LOX1 Antibody Pair - BSA and Azide free (ab241730)

    Key features and details

    • Unconjugated capture and detector antibodies
    • Adaptable to any antibody pair-based assay format
    • Antibody concentration ~ 1 mg/ml
    • BSA and azide free buffer - ready for conjugation
    • Reacts with: Mouse

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    Overview

    • Product name

      Mouse LOX1 Antibody Pair - BSA and Azide free
      See all LOX 1 kits
    • Assay type

      ELISA set
    • Range

      15.62 pg/ml - 1000 pg/ml
    • Species reactivity

      Reacts with: Mouse
    • Product overview

      The Antibody Pair can be used to quantify Mouse LOX1. BSA and Azide free antibody pairs include unconjugated capture and detector antibodies suitable for sandwich ELISAs. The antibodies are provided at an approximate concentration of 1 mg/ml as measured by the protein A280 method. The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Both capture and detector antibodies are rabbit monoclonal antibodies delivering consistent, specific, and sensitive results.


      For additional information on the performance of the antibody pair, see the equivalent SimpleStep ELISA® Kit (ab204521), which uses the same antibodies. However, due to differences in their formulation, this antibody pair cannot be used with the consumables provided with our SimpleStep ELISA Kits. Please note that the range provided for the pairs is only an estimation based on the performance of the related product using the same antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody pair in your assay.


      Download SDS here.

    • Tested applications

      Suitable for: Sandwich ELISAmore details
    • Platform

      Reagents

    Properties

    • Storage instructions

      Store at +4°C. Please refer to protocols.
    • Carrier free

      Yes
    • Components 10 x 96 tests
      Mouse LOX1 Capture Antibody (unconjugated) 1 x 100µg
      Mouse LOX1 Detector Antibody (unconjugated) 1 x 100µg
    • Research areas

      • Cardiovascular
      • Lipids / Lipoproteins
      • Lipid Metabolism
      • Cholesterol Metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Cholesterol Metabolism
    • Function

      Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
    • Tissue specificity

      Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.
    • Involvement in disease

      Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.
      Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.
    • Sequence similarities

      Contains 1 C-type lectin domain.
    • Domain

      The cytoplasmic region is required for subcellular sorting on the cell surface.
      The C-type lectin domain mediates the recognition and binding of oxLDL.
    • Post-translational
      modifications

      The intrachain disulfide-bonds prevent N-glycosylation at some sites.
      N-glycosylated.
    • Cellular localization

      Cell membrane. Secreted. A secreted form also exists.
    • Target information above from: UniProt accession P78380 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Alternative names

      • C-type lectin domain family 8 member A
      • CLEC8A
      • hLOX 1
      • hLOX-1
      • Lectin like oxidized LDL receptor 1
      • Lectin like oxLDL receptor 1
      • Lectin type oxidized LDL receptor 1
      • Lectin-like oxidized LDL receptor 1
      • Lectin-like oxLDL receptor 1
      • Lectin-type oxidized LDL receptor 1
      • low density lipoprotein oxidized, receptor 1
      • LOX-1
      • LOXIN
      • Olr1
      • OLR1_HUMAN
      • Ox LDL receptor 1
      • Ox-LDL receptor 1
      • Oxidised low density lipoprotein (lectin like) receptor 1
      • Oxidized low density lipoprotein receptor 1
      • Oxidized low density lipoprotein receptor 1 soluble form
      • Oxidized low-density lipoprotein receptor 1
      • OxLDL receptor 1
      • SCARE1
      • Scavenger receptor class E, member 1
      • SLOX1
      • soluble form
      • SR-EI
      see all
    • Database links

      • Entrez Gene: 108078 Mouse
      • SwissProt: Q9EQ09 Mouse
      • Unigene: 293626 Mouse

      Associated products

      • Alternative Versions

        • Mouse LOX1 Matched Antibody Pair Kit (ab215079)

      Applications

      Our Abpromise guarantee covers the use of ab241730 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      Application Abreviews Notes
      Sandwich ELISA Use at an assay dependent concentration.

      Images

      • Sandwich ELISA - Mouse LOX1 Antibody Pair - BSA and Azide free (ab241730)
        Sandwich ELISA - Mouse LOX1 Antibody Pair - BSA and Azide free (ab241730)
        To learn more about the advantages of recombinant antibodies see here.

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab241730? Please let us know so that we can cite the reference in this datasheet.

      ab241730 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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