Associated products


Our Abpromise guarantee covers the use of ab30845 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form

  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names

    • CD 108
    • CD108
    • CD108 antigen
    • CDw108
    • H Sema K1
    • H Sema L
    • H-SEMA-K1
    • H-Sema-L
    • JMH
    • JMH blood group antigen
    • John Milton Hagen blood group H Sema K1
    • John Milton Hargen human blood group Ag
    • John-Milton-Hargen human blood group Ag
    • MGC126692
    • MGC126696
    • Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A
    • Sema K1
    • Sema L
    • SEMA7A
    • SEMAK1
    • SEMAL
    • Semaphorin 7A GPI membrane anchor
    • Semaphorin K1
    • Semaphorin L
    • Semaphorin-7A
    • Semaphorin-K1
    • Semaphorin-L
    • Semaphorin7a
    see all
  • Function

    Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
  • Tissue specificity

    Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.
  • Sequence similarities

    Belongs to the semaphorin family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 PSI domain.
    Contains 1 Sema domain.
  • Cellular localization

    Cell membrane. Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
  • Information by UniProt


ab30845 has not yet been referenced specifically in any publications.

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