Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab209050 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form

    Liquid
  • Additional notes

    This is the blocking peptide for ab103021

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • Protein unc-84 homolog A
    • Sad1 and UNC84 domain containing 1
    • Sad1/unc 84 protein like 1
    • Sad1/unc-84 protein-like 1
    • Sun domain-containing protein 1
    • Sun1
    • SUN1_HUMAN
    • UNC 84 homolog A (C elegans)
    • UNC 84A
    • UNC84
    • UNC84 A
    • UNC84 homolog A (C elegans)
    • UNC84A
    see all
  • Function

    Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs).
  • Sequence similarities

    Contains 1 SUN domain.
  • Domain

    The SUN domain may play a role in the nuclear anchoring and/or migration.
  • Cellular localization

    Nucleus inner membrane.
  • Information by UniProt

References

ab209050 has not yet been referenced specifically in any publications.

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