Associated products


Our Abpromise guarantee covers the use of ab39471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-TRPV4 antibody (ab39260)

  • Form

  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names

    • BCYM3
    • CMT2C
    • HMSN2C
    • osm 9 like TRP channel 4
    • Osm-9-like TRP channel 4
    • OSM9 like transient receptor potential channel 4
    • Osmosensitive transient receptor potential channel 4
    • OTRPC 4
    • OTRPC4
    • SMAL
    • SPSMA
    • SSQTL1
    • Transient receptor potential cation channel subfamily V member 4
    • Transient receptor potential protein 12
    • TRP 12
    • TRP12
    • TRPV 4
    • TrpV4
    • Vanilloid receptor like channel 2
    • Vanilloid receptor like protein 2
    • Vanilloid receptor related osmotically activated channel
    • Vanilloid receptor-like channel 2
    • Vanilloid receptor-like protein 2
    • Vanilloid receptor-related osmotically-activated channel
    • VR 4
    • VR OAC
    • VR-OAC
    • VR4
    • VRL 2
    • VRL-2
    • VRL2
    • VROAC
    see all
  • Function

    Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
  • Tissue specificity

    Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).
  • Involvement in disease

    Brachyolmia 3
    Spondylometaphyseal dysplasia Kozlowski type
    Metatropic dysplasia
    Distal spinal muscular atrophy, congenital non-progressive
    Charcot-Marie-Tooth disease 2C
    Scapuloperoneal spinal muscular atrophy
    Spondyloepiphyseal dysplasia Maroteaux type
    Parastremmatic dwarfism
    Digital arthropathy-brachydactyly, familial
  • Sequence similarities

    Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily.
    Contains 3 ANK repeats.
  • Post-translational

    Phosphorylation results in enhancement of its channel function.
  • Cellular localization

    Cell membrane and Cell membrane. Cell junction > adherens junction. Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum.
  • Information by UniProt


This product has been referenced in:

  • Heppner TJ  et al. Rhythmic Calcium Events in the Lamina Propria Network of the Urinary Bladder of Rat Pups. Front Syst Neurosci 11:87 (2017). Read more (PubMed: 29321730) »
  • Shahidullah M  et al. TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. Am J Physiol Cell Physiol 302:C1751-61 (2012). Blocking ; Pig . Read more (PubMed: 22492652) »
See all 2 Publications for this product

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