Overview

  • Product name

  • Description

    Rabbit polyclonal to MOX1/MEOX1
  • Host species

    Rabbit
  • Specificity

    Predicted to not crossreact with MOX2.
  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human MOX1/MEOX1 (internal sequence).
    Database link: NP_004518

  • Positive control

    • Human liver tissue lysate
  • General notes

     This product was previously labelled as MOX1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab105349 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 28 kDa.

Target

  • Function

    Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
  • Involvement in disease

    Klippel-Feil syndrome 2, autosomal recessive
  • Sequence similarities

    Contains 1 homeobox DNA-binding domain.
  • Cellular localization

    Nucleus. Cytoplasm. Localizes predominantly in the nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Homeobox protein MOX-1 antibody
    • MEOX1 antibody
    • MEOX1_HUMAN antibody
    • Mesenchyme homeo box 1 antibody
    • Mesenchyme homeobox 1 antibody
    • MOX 1 antibody
    • MOX1 antibody
    see all

Images

  • Immunofluorescence of MOX1/MEOX1 in rat liver tissue with ab105349 at 20 ug/mL.

  • Lane 1 : Anti-MOX1/MEOX1 antibody (ab105349) at 1 µg/ml
    Lane 2 : Anti-MOX1/MEOX1 antibody (ab105349) at 2 µg/ml

    All lanes : Human liver tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 28 kDa

References

This product has been referenced in:

  • Wu B  et al. Data on the involvement of Meox1 in balloon-injury-induced neointima formation of rats. Data Brief 16:266-270 (2018). Read more (PubMed: 29204471) »
See 1 Publication for this product

Customer reviews and Q&As

Application
Immunohistochemistry (Frozen sections)
Sample
Mouse Tissue sections (E8.5 and E10.5 mouse embryo)
Specification
E8.5 and E10.5 mouse embryo
Fixative
Paraformaldehyde
Permeabilization
Yes - PBST (PBS/0.5%v/v TritonX100 (Sigma)
Blocking step
1%BSA+5%serum(depend on secondary antibody) as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 25°C

Abcam user community

Verified customer

Submitted Jan 11 2012

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