Overview

  • Product name

    Mozavaptan, V2 receptor antagonist
  • Description

    Potent, selective, competitive V2 receptor antagonist
  • Biological description

    Potent, selective, competitive V2 receptor antagonist (IC50 values are 14 nM and 1.2 μM for V1 and V2 respectively). Inhibits the antidiuretic effects of arginine vasopressin in vivo.
  • Purity

    > 99%
  • CAS Number

    137975-06-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[4-[[5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methylbenzamide
  • Molecular weight

    427.54
  • Molecular formula

    C27H29N3O2
  • PubChem identifier

    119369
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N3CCCC(C4=CC=CC=C43)N(C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Roix J & Saha S TNF-a blockade is ineffective in animal models of established polycystic kidney disease. BMC Nephrol 14:233 (2013). Read more (PubMed: 24160989) »
  • Takada M  et al. Effects of arginine vasotocin and mesotocin on the activation and development of amiloride-blockable short-circuit current across larval, adult, and cultured larval bullfrog skins. J Comp Physiol B 180:393-402 (2010). Read more (PubMed: 19949800) »
  • Yeung PK  et al. Targeted overexpression of endothelin-1 in astrocytes leads to more severe cytotoxic brain edema and higher mortality. J Cereb Blood Flow Metab 29:1891-902 (2009). Read more (PubMed: 19707218) »

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