Recombinant
RabMAb

Recombinant Anti-MRC2/ENDO180 antibody [EPR13215] (ab181075)

Overview

  • Product name

    Anti-MRC2/ENDO180 antibody [EPR13215]
    See all MRC2/ENDO180 primary antibodies
  • Description

    Rabbit monoclonal [EPR13215] to MRC2/ENDO180
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human MRC2/ENDO180 aa 150-250. The exact sequence is proprietary.
    Database link: Q9UBG0

  • Positive control

    • Human fetal lung and kidney lysates; Saos 2 cell lysate.
  • General notes

     

     

     This product was previously labelled as MRC2

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.01% Sodium azide
    Constituents: 59% PBS, 40% Glycerol, 0.05% BSA
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR13215
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab181075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 180 kDa (predicted molecular weight: 167 kDa).

Target

  • Function

    May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs).
  • Tissue specificity

    Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney.
  • Sequence similarities

    Contains 8 C-type lectin domains.
    Contains 1 fibronectin type-II domain.
    Contains 1 ricin B-type lectin domain.
  • Domain

    C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
    Fibronectin type-II domain mediates collagen-binding.
    Ricin B-type lectin domain contacts with the second C-type lectin domain.
  • Post-translational
    modifications

    N-glycosylated.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • C-type lectin domain family 13 member E antibody
    • C-type mannose receptor 2 antibody
    • CD 280 antibody
    • CD280 antibody
    • CD280 antigen antibody
    • CLEC 13E antibody
    • CLEC13E antibody
    • ENDO 180 antibody
    • ENDO180 antibody
    • Endocytic receptor (macrophage mannose receptor family) antibody
    • Endocytic receptor 180 antibody
    • FLJ35911 antibody
    • KIAA0709 antibody
    • Macrophage mannose receptor 2 antibody
    • Mannose receptor C type 2 antibody
    • MRC 2 antibody
    • MRC2 antibody
    • MRC2_HUMAN antibody
    • UPAR-associated protein antibody
    • UPARAP antibody
    • Urokinase plasminogen activator receptor associated protein antibody
    • Urokinase receptor associated protein antibody
    • Urokinase receptor-associated protein antibody
    • Urokinase-type plasminogen activator receptor-associated protein antibody
    see all

Images

  • Anti-MRC2/ENDO180 antibody [EPR13215] (ab181075) at 1/5000 dilution + Saos 2 cell lysate at 20 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) (ab136636) at 1/500 dilution (Goat Anti-Rabbit IgG HRP)

    Predicted band size: 167 kDa

  • All lanes : Anti-MRC2/ENDO180 antibody [EPR13215] (ab181075) at 1/1000 dilution

    Lane 1 : Human fetal kidney lysate
    Lane 2 : Human fetal lung lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG H&L (HRP) (ab136636) at 1/500 dilution (Goat Anti-Rabbit IgG HRP)

    Predicted band size: 167 kDa

References

ab181075 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab181075.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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