Overview

  • Product name

  • Description

    Rabbit polyclonal to MRG15
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human MRG15 aa 96-323. The exact sequence is proprietary.
    Database link: Q9UBU8

  • Positive control

    • Huh7, Hep3B and mouse liver whole cell lysate/extract; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab183663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 41 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
  • Sequence similarities

    Belongs to the MRG family.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • CG6363 antibody
    • Eaf3 antibody
    • Esa1p associated factor 3 homolog antibody
    • FWP006 antibody
    • HsT17725 antibody
    • MEAF3 antibody
    • MO4L1_HUMAN antibody
    • MORF related gene on chromosome 15 antibody
    • MORF-related gene 15 protein antibody
    • Morf4l1 antibody
    • MORFRG15 antibody
    • Mortality factor 4 like 1 antibody
    • Mortality factor 4 like protein 1 antibody
    • Mortality factor 4-like protein 1 antibody
    • MRG15 antibody
    • Protein MSL3-1 antibody
    • S863-6 antibody
    • Transcription factor-like protein MRG15 antibody
    see all

Images

  • All lanes : Anti-MRG15 antibody (ab183663) at 1/500 dilution

    Lane 1 : Huh7 whole cell lysate/extract
    Lane 2 : Hep3B whole cell lysate/extract

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 41 kDa



    10 % SDS-PAGE

  • Anti-MRG15 antibody (ab183663) at 1/500 dilution + Mouse liver lysate/extract at 50 µg

    Predicted band size: 41 kDa



    10 % SDS-PAGE

  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells labeling MRG15 with ab183663 at 1/1000 dilution (green). The slide on the right is counterstained with Hoechst 33342 (blue).

References

This product has been referenced in:

  • Charoy C  et al. Genetic specification of left-right asymmetry in the diaphragm muscles and their motor innervation. Elife 6:N/A (2017). WB ; Mouse . Read more (PubMed: 28639940) »
See 1 Publication for this product

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