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Signal Transduction Signaling Pathway G Protein Signaling GPCR
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Anti-MRGX3 antibody - Extracellular domain (ab140863)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (ab140863)

    Key features and details

    • Rabbit polyclonal to MRGX3 - Extracellular domain
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human MRGX3 protein (ab165130)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-MRGX3 antibody - Extracellular domain
      See all MRGX3 primary antibodies
    • Description

      Rabbit polyclonal to MRGX3 - Extracellular domain
    • Host species

      Rabbit
    • Specificity

      BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except MRGPRX4 (59%), LRRK2 (53%), CACNB4 (47%).
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Gorilla
    • Immunogen

      A 17 amino acid synthetic peptide from the first extracellular domain of Human MRGX3 (NP_473372.2).

    • Positive control

      • Human Brain Cerebellum tissue (Purkinje Neurons).
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C.
    • Storage buffer

      Preservative: 0.1% Sodium azide
      Constituent: 99% PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Neuroscience
      • Sensory System
      • Somatosensory system
      • Nociception

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human MRGX3 protein (ab165130)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab140863 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use a concentration of 21 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    Notes
    IHC-P
    Use a concentration of 21 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins.
    • Tissue specificity

      Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
    • Sequence similarities

      Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
    • Cellular localization

      Cell membrane.
    • Target information above from: UniProt accession Q96LB0 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 101132846 Gorilla
      • Entrez Gene: 117195 Human
      • Omim: 607229 Human
      • SwissProt: Q96LB0 Human
      • Unigene: 380177 Human
      • Alternative names

        • G protein coupled receptor SNSR1 antibody
        • G protein coupled receptor SNSR2 antibody
        • G protein-coupled receptor MRGX 3 antibody
        • G protein-coupled receptor MRGX3 antibody
        • GPCR antibody
        • Mas related GPCR member X3 antibody
        • Mas-related G protein coupled MRGX 3 antibody
        • Mas-related G protein coupled MRGX3 antibody
        • Mas-related G-protein coupled receptor member X3 antibody
        • MAS-related GPR, member X3 antibody
        • MRGPRX3 antibody
        • MRGX3 antibody
        • MRGX3_HUMAN antibody
        • Sensory neuron-specific G-protein coupled receptor 1 antibody
        • Sensory neuron-specific G-protein coupled receptor 1/2 antibody
        • SNSR1 antibody
        • SNSR2 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (ab140863)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (ab140863)
        Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Brain Cerebellum (Purkinje Neurons) tissue labelling MRGX3 with ab140863 at 21 µg/ml.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (1)

      Publishing research using ab140863? Please let us know so that we can cite the reference in this datasheet.

      ab140863 has been referenced in 1 publication.

      • Yoshihara M  et al. Discovery of molecular markers to discriminate corneal endothelial cells in the human body. PLoS One 10:e0117581 (2015). PubMed: 25807145

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