Anti-MRGX3 antibody - Extracellular domain (ab140863)
Key features and details
- Rabbit polyclonal to MRGX3 - Extracellular domain
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-MRGX3 antibody - Extracellular domain
See all MRGX3 primary antibodies -
Description
Rabbit polyclonal to MRGX3 - Extracellular domain -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except MRGPRX4 (59%), LRRK2 (53%), CACNB4 (47%). -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Gorilla
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Immunogen
A 17 amino acid synthetic peptide from the first extracellular domain of Human MRGX3 (NP_473372.2).
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Positive control
- Human Brain Cerebellum tissue (Purkinje Neurons).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab140863 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
Use a concentration of 21 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| Notes |
|---|
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IHC-P
Use a concentration of 21 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins. -
Tissue specificity
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Mas subfamily. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 101132846 Gorilla
- Entrez Gene: 117195 Human
- Omim: 607229 Human
- SwissProt: Q96LB0 Human
- Unigene: 380177 Human
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Alternative names
- G protein coupled receptor SNSR1 antibody
- G protein coupled receptor SNSR2 antibody
- G protein-coupled receptor MRGX 3 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (ab140863)Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Brain Cerebellum (Purkinje Neurons) tissue labelling MRGX3 with ab140863 at 21 µg/ml.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab140863 has been referenced in 1 publication.
- Yoshihara M et al. Discovery of molecular markers to discriminate corneal endothelial cells in the human body. PLoS One 10:e0117581 (2015). PubMed: 25807145