Anti-MRGX3 antibody - Extracellular domain (ab140863)

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Overview

  • Product name

    Anti-MRGX3 antibody - Extracellular domain
    See all MRGX3 primary antibodies

  • Description

    Rabbit polyclonal to MRGX3 - Extracellular domain

  • Host species

    Rabbit

  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except MRGPRX4 (59%), LRRK2 (53%), CACNB4 (47%).

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Gorilla

  • Immunogen

    A 17 amino acid synthetic peptide from the first extracellular domain of Human MRGX3 (NP_473372.2).

  • Positive control

    • Human Brain Cerebellum tissue (Purkinje Neurons).

Properties

Applications

Our Abpromise guarantee covers the use of ab140863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 21 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins.

  • Tissue specificity

    Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

  • Cellular localization

    Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • G protein coupled receptor SNSR1 antibody
      • G protein coupled receptor SNSR2 antibody
      • G protein-coupled receptor MRGX 3 antibody
      • G protein-coupled receptor MRGX3 antibody
      • GPCR antibody
      • Mas related GPCR member X3 antibody
      • Mas-related G protein coupled MRGX 3 antibody
      • Mas-related G protein coupled MRGX3 antibody
      • Mas-related G-protein coupled receptor member X3 antibody
      • MAS-related GPR, member X3 antibody
      • MRGPRX3 antibody
      • MRGX3 antibody
      • MRGX3_HUMAN antibody
      • Sensory neuron-specific G-protein coupled receptor 1 antibody
      • Sensory neuron-specific G-protein coupled receptor 1/2 antibody
      • SNSR1 antibody
      • SNSR2 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (ab140863)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRGX3 antibody - Extracellular domain (ab140863)
      Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Brain Cerebellum (Purkinje Neurons) tissue labelling MRGX3 with ab140863 at 21 µg/ml.

    References

    This product has been referenced in:

    • Yoshihara M  et al. Discovery of molecular markers to discriminate corneal endothelial cells in the human body. PLoS One 10:e0117581 (2015). Read more (PubMed: 25807145) »
    See 1 Publication for this product

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