Anti-MRP2 antibody [M2 III-6] (ab3373)

ab3373 has been referenced in 47 publications.

• Xiao Y  et al. Quercetin and kaempferol increase the intestinal absorption of isorhamnetin coexisting in Elaeagnus rhamnoides (L.) A. Nelson (Elaeagnaceae) extracts via regulating multidrug resistance-associated protein 2. Phytomedicine 53:154-162 (2019). PubMed: 30668394
• Myint K  et al. Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer. Sci Rep 9:2245 (2019). PubMed: 30783141
• Costantini D  et al. Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells. Sci Rep 9:5559 (2019). PubMed: 30944365
• Lu M  et al. Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress. Hepatology 68:317-332 (2018). PubMed: 29356040
• Madden LR  et al. Bioprinted 3D Primary Human Intestinal Tissues Model Aspects of Native Physiology and ADME/Tox Functions. iScience 2:156-167 (2018). PubMed: 30428372
• Wu L  et al. Mutation analysis of the ABCC2 gene in Chinese patients with Dubin-Johnson syndrome. Exp Ther Med 16:4201-4206 (2018). PubMed: 30344695
• Freyer N  et al. Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions. Bioengineering (Basel) 5:N/A (2018). IHC ; Human . PubMed: 29543727
• Jang M  et al. Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform. Biomed Microdevices 20:54 (2018). PubMed: 29946898
• Zhang Y  et al. ETS1 is associated with cisplatin resistance through IKKa/NF-?B pathway in cell line MDA-MB-231. Cancer Cell Int 18:86 (2018). PubMed: 29950928
• Zukauskas A  et al. Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection. mSphere 3:N/A (2018). PubMed: 29976647
• Sun L  et al. HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins. J Cancer 8:2802-2808 (2017). PubMed: 28928869
• Dash A  et al. Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro 39:93-103 (2017). PubMed: 27939613
• Ma Q  et al. Hypoxia promotes chemotherapy resistance by down-regulating SKA1 gene expression in human osteosarcoma. Cancer Biol Ther 18:177-185 (2017). PubMed: 28278080
• Grewal GK  et al. In Vitro Assessment of the Effect of Antiepileptic Drugs on Expression and Function of ABC Transporters and Their Interactions with ABCC2. Molecules 22:N/A (2017). PubMed: 28961159
• Ramaiahgari SC  et al. From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening. Toxicol Sci 159:124-136 (2017). PubMed: 28633424
• Casey CA  et al. Study of Ethanol-Induced Golgi Disorganization Reveals the Potential Mechanism of Alcohol-Impaired N-Glycosylation. Alcohol Clin Exp Res 40:2573-2590 (2016). PubMed: 27748959
• Chow EC  et al. Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters. Drug Metab Dispos 44:1524-35 (2016). WB ; Human . PubMed: 27342868
• Imada S  et al. Central bisectionectomy for hepatocellular carcinoma in a patient with indocyanine green excretory defect associated with reduced expression of the liver transporter. Surg Case Rep 2:89 (2016). PubMed: 27589984
• Topalis D  et al. Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1. Oncotarget 7:10386-401 (2016). WB . PubMed: 26824416
• Bell CC  et al. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Sci Rep 6:25187 (2016). IHC-Fr ; Human . PubMed: 27143246
• Kwon MH  et al. Effects of poloxamer 407-induced hyperlipidemia on hepatic multidrug resistance protein 2 (Mrp2/Abcc2) and the pharmacokinetics of mycophenolic acid in rats. Biopharm Drug Dispos 37:352-65 (2016). PubMed: 27241939
• Hendriks DF  et al. Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability. Sci Rep 6:35434 (2016). IHC-P ; Human . PubMed: 27759057
• Campia I  et al. An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS One 10:e0126159 (2015). WB . PubMed: 25955018
• Lou YR  et al. Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells. Sci Rep 5:13635 (2015). PubMed: 26323570
• Liu X  et al. Significance of the expression of MRP1 and MRP2 in peripheral blood mononuclear cells of children with intractable epilepsy. Exp Ther Med 10:1784-1788 (2015). WB . PubMed: 26640550
• Ding L  et al. Danning tablets attenuates a-naphthylisothiocyanate-induced cholestasis by modulating the expression of transporters and metabolic enzymes. BMC Complement Altern Med 14:249 (2014). WB . PubMed: 25033983
• Gieseck RL  et al. Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture. PLoS One 9:e86372 (2014). ICC/IF ; Human . PubMed: 24466060
• Zalups RK  et al. Novel Hg2+-Induced Nephropathy in Rats and Mice Lacking Mrp2: Evidence of Axial Heterogeneity in the Handling of Hg2+ Along the Proximal Tubule. Toxicol Sci N/A:N/A (2014). WB ; Rat . PubMed: 25145654
• Kawase A  et al. Decreased radixin function for ATP-binding cassette transporters in liver in adjuvant-induced arthritis rats. J Pharm Sci 103:4058-65 (2014). PubMed: 25331966
• Sourisseau M  et al. Temporal analysis of hepatitis C virus cell entry with occludin directed blocking antibodies. PLoS Pathog 9:e1003244 (2013). ICC/IF ; Human . PubMed: 23555257
• Dash A  et al. Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro. Am J Physiol Cell Physiol 304:C1053-63 (2013). PubMed: 23485712
• Kim HS  et al. Expression of multidrug resistance-associated protein 2 in human gallbladder carcinoma. Biomed Res Int 2013:527534 (2013). IHC-P ; Human . PubMed: 23841074
• Gunness P  et al. 3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies. Toxicol Sci 133:67-78 (2013). PubMed: 23377618
• Mirakhorli M  et al. Lack of association between expression of MRP2 and early relapse of colorectal cancer in patients receiving FOLFOX-4 chemotherapy. Oncol Lett 4:893-897 (2012). PubMed: 23162618
• Foster JR  et al. Differential effect of troglitazone on the human bile acid transporters, MRP2 and BSEP, in the PXB hepatic chimeric mouse. Toxicol Pathol 40:1106-16 (2012). PubMed: 22673116
• Anger GJ  et al. Expression of ABC Efflux Transporters in Placenta from Women with Insulin-Managed Diabetes. PLoS One 7:e35027 (2012). WB ; Human . PubMed: 22558111
• Greaves W  et al. Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols. J Hematol Oncol 5:47 (2012). IHC-P ; Human . PubMed: 22871336
• Leitch S  et al. Vesicular distribution of Secretory Pathway Ca²+-ATPase isoform 1 and a role in manganese detoxification in liver-derived polarized cells. Biometals 24:159-70 (2011). ICC/IF ; Human . PubMed: 20981470
• Martin P  et al. Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells. Acta Pharmacol Sin 31:51-65 (2010). WB . PubMed: 20048746
• Petrovic V & Piquette-Miller M Impact of polyinosinic/polycytidylic acid on placental and hepatobiliary drug transporters in pregnant rats. Drug Metab Dispos 38:1760-6 (2010). PubMed: 20610559
• Vellonen KS  et al. Effluxing ABC transporters in human corneal epithelium. J Pharm Sci 99:1087-98 (2010). WB ; Human . PubMed: 19623615
• Mannermaa E  et al. Efflux protein expression in human retinal pigment epithelium cell lines. Pharm Res 26:1785-91 (2009). WB ; Human . PubMed: 19384462
• Fan J  et al. Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer. J Pharmacol Exp Ther 330:389-402 (2009). PubMed: 19414624
• Mee CJ  et al. Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells. J Virol 83:6211-21 (2009). PubMed: 19357163
• Liptrott NJ  et al. Detection of ABCC2, CYP2B6 and CYP3A4 in human peripheral blood mononuclear cells using flow cytometry. J Immunol Methods 339:270-4 (2008). Flow Cyt ; Human . PubMed: 18929567
• Martin P  et al. Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells. Br J Pharmacol 153:805-19 (2008). PubMed: 18037906
• Herrema H  et al. Rho kinase, myosin-II, and p42/44 MAPK control extracellular matrix-mediated apical bile canalicular lumen morphogenesis in HepG2 cells. Mol Biol Cell 17:3291-303 (2006). PubMed: 16687572