Product nameAnti-MRP2 antibody [M2II-12]
See all MRP2 primary antibodies
DescriptionMouse monoclonal [M2II-12] to MRP2
Specificityab24106 reacts with MRP2 (ABCC2) and does not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.
Tested applicationsSuitable for: ICC, Flow Cyt, WB, IHC-Frmore details
Species reactivityReacts with: Human
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.1% Sodium azide
Constituents: Tissue culture supernatant, 0.7% BSA
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab24106 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC: Use at 1/20-1/50 dilution on acetone fixed cytospin preparations.
IHC-Fr: Use at 1/20 dilution. Acetone fixed.
WB: 1/20-1/50. Detects a band of approximately 190-200 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionMediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Tissue specificityFound on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Involvement in diseaseDefects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
Sequence similaritiesBelongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
- Information by UniProt
- ABC30 antibody
- abcC2 antibody
- ATP binding cassette sub family C (CFTR/MRP) member 2 antibody
ab24106 has not yet been referenced specifically in any publications.