• Product name
    Anti-MRP2 antibody [M2III-5]
    See all MRP2 primary antibodies
  • Description
    Mouse monoclonal [M2III-5] to MRP2
  • Host species
  • Specificity
    This antibody does not cross-react with the human MDR1 P-gp, MRP1, MRP3, or MRP5 gene products.
  • Tested applications
    Suitable for: WB, Flow Cyt, ICC, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Rat, Human
    Does not react with: Mouse
  • Immunogen

    This antibody was raised against a fusion protein of the bacterial maltose binding protein and rat MRP2, containing the 202-amino acid C terminal end of the transporter protein.

  • Epitope
    ab15603 reacts with an internal epitope of MRP2; a 190-200 kD transmembrane protein earlier known as the canalicular multi-organic anion transporter cMOAT, absent in patients with the Dubin-Johnson syndrome.



Our Abpromise guarantee covers the use of ab15603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/20 - 1/50. Predicted molecular weight: 185.4 kDa.
Flow Cyt Use at an assay dependent concentration.

ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.


ICC 1/20 - 1/50. Acetone fixed cytospin preparations.
IHC-P 1/20. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-Fr 1/20. Acetone fixed.


  • Function
    Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
  • Tissue specificity
    Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
  • Involvement in disease
    Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
  • Sequence similarities
    Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • ABC30 antibody
    • abcC2 antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 2 antibody
    • ATP binding cassette subfamily C member 2 antibody
    • ATP-binding cassette sub-family C member 2 antibody
    • Canalicular multidrug resistance protein antibody
    • Canalicular multispecific organic anion transporter 1 antibody
    • CMOAT antibody
    • CMOAT1 antibody
    • cMRP antibody
    • DJS antibody
    • KIAA1010 antibody
    • MRP 2 antibody
    • MRP2_HUMAN antibody
    • Multidrug resistance associated protein 2 antibody
    • Multidrug resistance-associated protein 2 antibody
    see all


This product has been referenced in:
  • Kataoka J  et al. Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma. Oncol Rep 35:2576-82 (2016). IHC . Read more (PubMed: 26985715) »
  • Hardwick RN  et al. Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. Drug Metab Dispos 40:450-60 (2012). WB ; Rat . Read more (PubMed: 22112382) »

See all 8 Publications for this product

Customer reviews and Q&As

Thank you for contacting us.

The note regarding mouse specificity is based on data from the following reference, which includes a description of the clone's development and characterization:

Cancer Res. 2000 Sep 15;60(18):5269-77....

Read More

Thank you very much for your inquiry and your patience while waiting for our answer.

I have inquired with the laboratories of the polyclonal antibodies, whether the immunogen sequence is conserved with the pig sequence. This would then provid...

Read More

Thank you for your feedback regarding this product. As a result of the information that you have sent to me and references sourced via “Pub Med” I have currently removed cross reactivity with from our product data base. I would like to thank you for th...

Read More


Sign up