Overview

  • Product name

    Anti-MRP8 antibody - N-terminal
    See all MRP8 primary antibodies
  • Description

    Rabbit polyclonal to MRP8 - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human MRP8 aa 1-170 (N terminal).
    Sequence:

    MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNP EAPGRAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWL TPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEKAS VLLVMLRFQRTRLIFDALLG


    Database link: Q96J66

  • Positive control

    • IHC-P: Human breast cancer and testis tissues.
  • General notes

     This product was previously labelled as ABCC11

     

Properties

Applications

Our Abpromise guarantee covers the use of ab229741 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.
  • Tissue specificity

    Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, brain and placenta.
  • Sequence similarities

    Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ABCC 11 antibody
    • ABCC11 antibody
    • ABCCB_HUMAN antibody
    • ATP binding cassette protein C11 antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 11 antibody
    • ATP binding cassette sub family C member 11 antibody
    • ATP binding cassette transporter MRP8 antibody
    • ATP binding cassette transporter sub family C member 11 antibody
    • ATP-binding cassette sub-family C member 11 antibody
    • EWWD antibody
    • MRP8 antibody
    • Multi resistance protein 8 antibody
    • Multidrug resistance associated protein 8 antibody
    • Multidrug resistance-associated protein 8 antibody
    • OTTHUMP00000164191 antibody
    • WW antibody
    see all

Images

  • Paraffin-embedded human testis tissue stained for MRP8 using ab229741 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human breast cancer tissue stained for MRP8 using ab229741 at 1/100 dilution in immunohistochemical analysis.

References

ab229741 has not yet been referenced specifically in any publications.

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