Anti-MRP8 + MRP14 antibody [5.5] (ab20222)
Key features and details
- Mouse monoclonal [5.5] to MRP8 + MRP14
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-MRP8 + MRP14 antibody [5.5]
See all MRP8 + MRP14 primary antibodies -
Description
Mouse monoclonal [5.5] to MRP8 + MRP14 -
Host species
Mouse -
Species reactivity
Reacts with: Human -
Immunogen
Tissue/ cell preparation, acute monocytic leukaemia cells (Human).
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Positive control
- Neutrophil lysate (particularly neutrophils from spleen)
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: PBS -
Concentration information loading... -
Purity
Protein A/G purified -
Clonality
Monoclonal -
Clone number
5.5 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Target
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Relevance
MRP8 and MRP14 are members of the S100 family of proteins containing 2 EF hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. -
Cellular localization
Cytoplasmic and Nuclear -
Database links
- Entrez Gene: 6279 Human
- Entrez Gene: 6280 Human
- Omim: 123885 Human
- Omim: 123886 Human
- SwissProt: P05109 Human
- SwissProt: P06702 Human
- Unigene: 112405 Human
- Unigene: 416073 Human
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Alternative names
- CAGA antibody
- CAGB antibody
- Calgranulin A antibody
see all
Protocols
References (4)
ab20222 has been referenced in 4 publications.
- Wen H et al. Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma. Nat Med 24:154-164 (2018). WB . PubMed: 29291352
- Wang Y et al. Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis. J Clin Invest 124:2160-71 (2014). WB, IHC ; Mouse . PubMed: 24691441
- Hessian PA & Fisher L The heterodimeric complex of MRP-8 (S100A8) and MRP-14 (S100A9). Antibody recognition, epitope definition and the implications for structure. Eur J Biochem 268:353-63 (2001). PubMed: 11168370
- Hogg N et al. Monoclonal antibody 5.5 reacts with p8,14, a myeloid molecule associated with some vascular endothelium. Eur J Immunol 19:1053-61 (1989). PubMed: 2666142
