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    mrpl41-antibody-ab121821.pdf

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Cell Biology Cell Cycle Cell Cycle Inhibitors Cip / Kip
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Anti-MRPL41 antibody (ab121821)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL41 antibody (ab121821)
  • Western blot - Anti-MRPL41 antibody (ab121821)
  • Immunocytochemistry/ Immunofluorescence - Anti-MRPL41 antibody (ab121821)

Key features and details

  • Rabbit polyclonal to MRPL41
  • Suitable for: IHC-P, WB, ICC/IF
  • Reacts with: Human
  • Isotype: IgG

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Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-MRPL41 antibody
  • Description

    Rabbit polyclonal to MRPL41
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    antigen sequence: KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR, corresponding to amino acids 71-137 of Human MRPL41.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • Human rectum tissue; RT-4 and U-251 MG cell lysates; U-251MG cells
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Cell Cycle
    • Cell Cycle Inhibitors
    • Cip / Kip
    • Cell Biology
    • Cell Cycle
    • Cell Cycle Inhibitors
    • p53
    • Cell Biology
    • Apoptosis
    • Intracellular
    • p53 Pathway
    • Tags & Cell Markers
    • Subcellular Markers
    • Organelles
    • Mitochondria
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • Translation
    • Ribosome
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • Translation
    • Mito. Translation
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Cell Cycle Inhibitors
    • Cip/Kip
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Cell Cycle Inhibitors
    • p53

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

Our Abpromise guarantee covers the use of ab121821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 0.04 - 0.4 µg/ml.
ICC/IF Use a concentration of 0.25 - 2 µg/ml.

Target

  • Function

    Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
  • Tissue specificity

    Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
  • Sequence similarities

    Belongs to the ribosomal protein L41 family.
  • Cellular localization

    Mitochondrion.
  • Target information above from: UniProt accession Q8IXM3 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 64975 Human
    • Omim: 611846 Human
    • SwissProt: Q8IXM3 Human
    • Unigene: 44017 Human
    • Alternative names

      • 39S ribosomal protein L27 homolog antibody
      • 39S ribosomal protein L41 antibody
      • 39S ribosomal protein L41 mitochondrial antibody
      • Bcl-2-interacting mitochondrial ribosomal protein L41 antibody
      • BMRP antibody
      • Cell proliferation-inducing gene 3 protein antibody
      • L41mt antibody
      • mitochondrial antibody
      • Mitochondrial ribosomal protein L41 antibody
      • MRP L27 antibody
      • MRP-L27 homolog antibody
      • MRP-L41 antibody
      • MRPL27 antibody
      • mRpL41 antibody
      • PIG3 antibody
      • Proliferation inducing gene 3 antibody
      • RM41_HUMAN antibody
      • RPML27 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL41 antibody (ab121821)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL41 antibody (ab121821)
      ab121821, at 1/300 dilution, staining MRPL41 in paraffin-embedded Human rectum tissue by Immunohistochemistry.
    • Western blot - Anti-MRPL41 antibody (ab121821)
      Western blot - Anti-MRPL41 antibody (ab121821)
      All lanes : Anti-MRPL41 antibody (ab121821) at 1/250 dilution

      Lane 1 : RT-4 cell lysate
      Lane 2 : U-251 MG cell lysate
      Lane 3 : Human Plasma lysate
      Lane 4 : Human Liver lysate
      Lane 5 : Human Tonsil lysate
    • Immunocytochemistry/ Immunofluorescence - Anti-MRPL41 antibody (ab121821)
      Immunocytochemistry/ Immunofluorescence - Anti-MRPL41 antibody (ab121821)
      ab121821, at 4µg/ml, staining MRPL41 in U-251MG cells by Immunofluorescence. Antibody staining is shown in green.

    Protocols

    • Immunohistochemistry protocols
    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab121821? Please let us know so that we can cite the reference in this datasheet.

    ab121821 has not yet been referenced specifically in any publications.

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