Overview

  • Product name

  • Description

    Rabbit polyclonal to MSF
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 536-586 of Human MSF (NP_001106963.1).

  • Positive control

    • Human Breast Carcinoma, Colon Carcinoma, Prostate Carcinoma and Stomach Adenocarcinoma tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituents: 99% Tris buffered saline, 0.1% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab117832 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
  • Tissue specificity

    Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues.
  • Involvement in disease

    Note=A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with MLL.
    Defects in SEPT9 are a cause of hereditary neuralgic amyotrophy (HNA) [MIM:162100]; also known as neuritis with brachial predilection (NAPB) or hereditary brachial plexus neuropathy or hereditary neuralgic amyotrophy with predilection for brachial plexus. HNA is an autosomal dominant form of recurrent focal neuropathy characterized clinically by acute, recurrent episodes of brachial plexus neuropathy with muscle weakness and atrophy preceded by severe pain in the affected arm. HNA is triggered by environmental factors such as infection or parturition.
  • Sequence similarities

    Belongs to the septin family.
  • Cellular localization

    Cytoplasm > cytoskeleton. In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
  • Information by UniProt
  • Database links

  • Alternative names

    • AF17q25 antibody
    • Cell division control protein septin D1 antibody
    • KIAA0991 antibody
    • MLL septin like fusion protein antibody
    • MLL septin-like fusion protein antibody
    • MLL septin-like fusion protein MSF-A antibody
    • MSF antibody
    • MSF1 antibody
    • NAPB antibody
    • Ov/Br septin antibody
    • Ovarian/breast septin alpha antibody
    • Ovarian/Breast septin antibody
    • PNUTL4 antibody
    • SEPT9 antibody
    • SEPT9_HUMAN antibody
    • SeptD1 antibody
    • Septin 9 antibody
    • Septin D1 antibody
    • Septin-9 antibody
    • SINT1 antibody
    see all

Images

  • Immunofluorescent analysis of Human MSF detection in Paraffin-embedded, Formalin-fixed Human Prostate carcinoma tissue using 1/100 ab117832. Detection:Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated used at a dilution of 1/100.
  • Immunohistochemical analysis of MSF expression in Formalin-fixed, Paraffin-embedded Human breast carcinoma using 1/250 ab117832. Detection: DAB staining.

References

ab117832 has not yet been referenced specifically in any publications.

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