• Product name

  • Description

    Rabbit polyclonal to MSH3
  • Host species

  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human MSH3 aa 350-450 (internal sequence). The exact sequence is proprietary.
    Database link: P20585

  • Positive control

    • Human rectal carcinoma tissue


  • Form

  • Storage instructions

    Shipped at 4°C. Store at +4°C.
  • Storage buffer

    pH: 7.6
    Preservative: 0.1% Sodium azide
    Constituents: PBS, 1% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    Immunogen affinity purified immunoglobulin from rabbit serum.
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab93663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 5 µg/ml.


  • Function

    Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
  • Involvement in disease

    Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC) [MIM:608089].
  • Sequence similarities

    Belongs to the DNA mismatch repair mutS family. MSH3 subfamily.
  • Post-translational

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt
  • Database links

  • Alternative names

    • Divergent upstream protein antibody
    • DNA mismatch repair protein antibody
    • DNA mismatch repair protein Msh 3 antibody
    • DNA mismatch repair protein MSH3 antibody
    • DUC 1 antibody
    • DUC1 antibody
    • DUG antibody
    • DUP antibody
    • hMSH3 antibody
    • MGC163306 antibody
    • MGC163308 antibody
    • Mismatch repair protein 1 antibody
    • MRP 1 antibody
    • MRP1 antibody
    • MSH 3 antibody
    • MSH3 antibody
    • MSH3_HUMAN antibody
    • MutS homolog 3 (E. coli) antibody
    • MutS homolog 3 antibody
    see all


  • ab93663, at a 1/100 dilution, staining MSH3 in formalin fixed, paraffin embedded Human rectal carcinoma tissue by Immunohistochemistry.
  • ICC/IF image of ab93663 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab93663, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h.Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.


ab93663 has not yet been referenced specifically in any publications.

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