Key features and details
- Suitable for: Blocking
Product namemSin3A peptide
Our Abpromise guarantee covers the use of ab4995 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the mouse mSin3A, catalog ab3479. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
FunctionActs as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST.
Sequence similaritiesContains 3 PAH (paired amphipathic helix) domains.
modificationsSUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.
Cellular localizationNucleus. Nucleus > nucleolus. Recruited to the nucleolus by SAP30L.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab4995 has been referenced in 1 publication.
- Kudva AK et al. Gelatin microspheres releasing transforming growth factor drive in vitro chondrogenesis of human periosteum derived cells in micromass culture. Acta Biomater 90:287-299 (2019). PubMed: 30905864