Overview

  • Product name

  • Description

    Rabbit polyclonal to MT3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Horse, Pig, Cynomolgus monkey
  • Immunogen

    Recombinant fragment corresponding to Human MT3 aa 1-65.
    Sequence:

    MDPETCPCPSGGSCTCADSCKCEGCKCTSCKKSCCSCCPAECEKCAKDCV CKGGEAAEAEAEKCS


    Database link: P25713

  • Positive control

    • IHC-P: Human cerebral cortex tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab224060 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.
  • Tissue specificity

    Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain.
  • Sequence similarities

    Belongs to the metallothionein superfamily. Type 1 family.
  • Information by UniProt
  • Database links

  • Alternative names

    • GIF antibody
    • GIFB antibody
    • GRIF antibody
    • Growth inhibitory factor antibody
    • Metallothionein 3 (growth inhibitory factor (neurotrophic)) antibody
    • Metallothionein 3 antibody
    • Metallothionein III antibody
    • Metallothionein-3 antibody
    • Metallothionein-III antibody
    • Mt 3 antibody
    • MT III antibody
    • MT-3 antibody
    • MT-III antibody
    • MT3 antibody
    • MT3_HUMAN antibody
    • ZnMT3 antibody
    see all

Images

  • Paraffin embedded human cerebral cortex tissue stained for MT3 with ab224060 (1/50 dilution) in immunohistochemical analysis.

References

ab224060 has not yet been referenced specifically in any publications.

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