Overview

  • Product name

  • Description

    Rabbit polyclonal to MTA1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Positive control

    • IHC-P: Human breast carcinoma tissue; Mouse ovary tissue; Rat hind brain tissue. ICC/IF: A431 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab226960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
  • Tissue specificity

    Widely expressed. High expression in brain, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual.
  • Sequence similarities

    Contains 1 BAH domain.
    Contains 1 ELM2 domain.
    Contains 1 GATA-type zinc finger.
    Contains 1 SANT domain.
  • Developmental stage

    Highly expressed in metastatic cells.
  • Domain

    Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif).
  • Cellular localization

    Cytoplasm and Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Metastasis associated 1 antibody
    • Metastasis associated gene 1 antibody
    • Metastasis associated gene 1 protein antibody
    • Metastasis associated protein antibody
    • Metastasis associated protein MTA 1 antibody
    • Metastasis associated protein MTA1 antibody
    • Metastasis-associated protein MTA1 antibody
    • MTA 1 antibody
    • MTA1 antibody
    • MTA1_HUMAN antibody
    see all

Images

  • 4% paraformaldehyde-fixed A431 (human epidermoid carcinoma cell line) cells stained for MTA1 (green) using ab226960 at 1/500 dilution in ICC/IF. Nuclear Counterstain: Hoechst 33342 (blue).

  • Paraffin-embedded rat hind brain tissue stained for MTA1 using ab226960 at 1/500 dilution in immunohistochemical analysis.

  • Paraffin-embedded mouse ovary tissue stained for MTA1 using ab226960 at 1/500 dilution in immunohistochemical analysis.

  • Paraffin-embedded human breast carcinoma tissue stained for MTA1 using ab226960 at 1/500 dilution in immunohistochemical analysis.

References

This product has been referenced in:

  • Wang Y  et al. Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/ß-Catenin Pathway. Med Sci Monit 24:9110-9119 (2018). Read more (PubMed: 30552850) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab226960.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up