Overview

  • Product name

  • Description

    Rabbit polyclonal to MTCO2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human MTCO2 (internal sequence).
    Database link: P00403

  • Positive control

    • Mouse heart tissue lysate; Human skin tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab198286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/5 - 1/50.
WB 1/150 - 1/2000. Predicted molecular weight: 25 kDa.

Target

  • Function

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
  • Involvement in disease

    Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • Sequence similarities

    Belongs to the cytochrome c oxidase subunit 2 family.
  • Cellular localization

    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • COII antibody
    • COX 2 antibody
    • COX II antibody
    • COX2 antibody
    • COX2_HUMAN antibody
    • COXII antibody
    • Cytochrome c oxidase II antibody
    • Cytochrome c oxidase polypeptide II antibody
    • Cytochrome c oxidase subunit 2 antibody
    • MT CO2 antibody
    • MT-CO2 antibody
    • MTCO2 antibody
    see all

Images

  • Anti-MTCO2 antibody (ab198286) at 1/150 dilution + Mouse heart tissue lysate at 30 µg

    Predicted band size: 25 kDa


    Exposure time: 30 seconds


    10% SDS-PAGE

  • Immunohistochemical analysis of paraffin embedded Human skin tissue labeling MTCO2 with ab198286 at 1/5 dilution dilution.

References

This product has been referenced in:

  • Chang HC  et al. Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells. Redox Biol 20:321-333 (2019). Read more (PubMed: 30391825) »
  • Basheer WA  et al. Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury. JCI Insight 3:N/A (2018). Read more (PubMed: 30333316) »
See all 3 Publications for this product

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