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Neuroscience Neurotransmitter Amino Acids Glutamate
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MTEP hydrochloride, mGlu5 antagonist (ab120035)

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  • SDS
  • COA
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Chemical Structure - MTEP hydrochloride, mGlu<sub>5</sub> antagonist (ab120035)

    Key features and details

    • Potent, selective mGlu5 antagonist
    • CAS Number: 1186195-60-7
    • Purity: > 99%
    • Soluble in water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      MTEP hydrochloride, mGlu5 antagonist
    • Description

      Potent, selective mGlu5 antagonist
    • Biological description

      Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Also available in Kit: mGlu antagonists (ab120322).

      Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration.

    • Purity

      > 99%
    • CAS Number

      1186195-60-7
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
    • Molecular weight

      236.72
    • Molecular formula

      C11H8N2S.HCl
    • PubChem identifier

      45073467
    • Storage instructions

      Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      Cc2nc(C#Cc1cccnc1)cs2.Cl
    • Source

      Synthetic

    • Research areas

      • Neuroscience
      • Neurotransmitter
      • Amino Acids
      • Glutamate
      • Neuroscience
      • Neurotransmission
      • Receptors / Channels
      • GPCR
      • Glutamate Receptors
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Pharmacology
      • Receptors & Transporters
      • Glutamate
      • mGlu
      • Group I
      • Antagonists
      • Biochemicals
      • Research Area
      • Addiction
      • Glutamate
      • mGlu
      • Group I
      • Antagonists
      • Biochemicals
      • Research Area
      • Alzheimer's Disease
      • Glutamate
      • mGlu
      • Group I
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      • Research Area
      • Depression
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      • mGlu
      • Group I
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      • Biochemicals
      • Research Area
      • Pain & inflammation
      • Glutamate
      • mGlu
      • Group I
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      • Biochemicals
      • Research Area
      • Parkinson's Disease
      • Glutamate
      • mGlu
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      • Biochemicals
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      • Schizophrenia
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      • mGlu
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      • Biochemicals
      • Research Area
      • Stroke
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      • mGlu
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    Associated products

      Images

      • Chemical Structure - MTEP hydrochloride, mGlu<sub>5</sub> antagonist (ab120035)
        Chemical Structure - MTEP hydrochloride, mGlu5 antagonist (ab120035)
        2D chemical structure image of ab120035, MTEP hydrochloride, mGlu5 antagonist

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download
      • COA

      References (22)

      Publishing research using ab120035? Please let us know so that we can cite the reference in this datasheet.

      ab120035 has been referenced in 22 publications.

      • Cannady R  et al. Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci 37:4359-4369 (2017). PubMed: 28320841
      • Travaglia A  et al. Infantile amnesia reflects a developmental critical period for hippocampal learning. Nat Neurosci 19:1225-33 (2016). PubMed: 27428652
      • Reese JN  et al. Role of spinal metabotropic glutamate receptor 5 in pudendal inhibition of the nociceptive bladder reflex in cats. Am J Physiol Renal Physiol 308:F832-8 (2015). PubMed: 25673810
      • Gass JT  et al. Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex. J Neurosci 34:7562-74 (2014). PubMed: 24872560
      • Kil KE  et al. Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4). J Med Chem 57:9130-8 (2014). PubMed: 25330258
      View all Publications for this product

      Customer reviews and Q&As

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