MTEP hydrochloride, mGlu5 antagonist (ab120035)
- Datasheet
- References (19)
Overview
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Product nameMTEP hydrochloride, mGlu5 antagonist
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DescriptionPotent, selective mGlu5 antagonist
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Biological descriptionBrain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Also available in Kit: mGlu antagonists (ab120322).
Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity> 99%
Properties
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Chemical name3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
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Molecular weight236.72
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Chemical structure
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Molecular formulaC11H8N2S.HCl
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CAS Number1186195-60-7
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PubChem identifier45073467
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Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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Solubility overviewSoluble in water to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESCc2nc(C#Cc1cccnc1)cs2.Cl
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Source
Synthetic
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Research areas
Associated products
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Related Products
References
This product has been referenced in:
- Varty GB et al. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. Psychopharmacology (Berl) 179:207-17 (2005). Read more (PubMed: 15682298) »
- Cosford ND et al. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem 46:204-6 (2003). Read more (PubMed: 12519057) »
- Anderson JJ et al. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol 473:35-40 (2003). Read more (PubMed: 12877935) »
