MTEP hydrochloride, mGlu5 antagonist (ab120035)
Key features and details
- Potent, selective mGlu5 antagonist
- CAS Number: 1186195-60-7
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
MTEP hydrochloride, mGlu5 antagonist -
Description
Potent, selective mGlu5 antagonist -
Biological description
Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Also available in Kit: mGlu antagonists (ab120322).
Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
CAS Number
1186195-60-7 -
Chemical structure
Properties
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Chemical name
3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride -
Molecular weight
236.72 -
Molecular formula
C11H8N2S.HCl -
PubChem identifier
45073467 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cc2nc(C#Cc1cccnc1)cs2.Cl -
Source
Synthetic
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Research areas
Associated products
Images
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Chemical Structure - MTEP hydrochloride, mGlu5 antagonist (ab120035)2D chemical structure image of ab120035, MTEP hydrochloride, mGlu5 antagonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (22)
ab120035 has been referenced in 22 publications.
- Cannady R et al. Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci 37:4359-4369 (2017). PubMed: 28320841
- Travaglia A et al. Infantile amnesia reflects a developmental critical period for hippocampal learning. Nat Neurosci 19:1225-33 (2016). PubMed: 27428652
- Reese JN et al. Role of spinal metabotropic glutamate receptor 5 in pudendal inhibition of the nociceptive bladder reflex in cats. Am J Physiol Renal Physiol 308:F832-8 (2015). PubMed: 25673810
- Gass JT et al. Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex. J Neurosci 34:7562-74 (2014). PubMed: 24872560
- Kil KE et al. Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4). J Med Chem 57:9130-8 (2014). PubMed: 25330258