Overview

  • Product name

    MTEP hydrochloride (mM/ml), mGlu5 antagonist
  • Description

    Potent, selective mGlu5 antagonist. 1 ml water soluble pack.
  • Biological description

    Brain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
  • Purity

    > 99%
  • CAS Number

    1186195-60-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
  • Molecular weight

    236.72
  • Molecular formula

    C11H8N2S.HCl
  • PubChem identifier

    45073467
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cc2nc(C#Cc1cccnc1)cs2.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Varty GB  et al. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. Psychopharmacology (Berl) 179:207-17 (2005). Read more (PubMed: 15682298) »
  • Cosford ND  et al. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem 46:204-6 (2003). Read more (PubMed: 12519057) »
  • Anderson JJ  et al. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol 473:35-40 (2003). Read more (PubMed: 12877935) »
See all 13 Publications for this product

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