Overview

  • Product name
    MTEP, mGluR5 antagonist
  • Description
    Potent and selective mGluR5 antagonist
  • Biological description
    Potent and selective mGluR5 antagonist. Acts as a negative allosteric modulator at mGluR5. Shows 5-fold more potent anxiolytic effects than MPEP (ab120008). Shows antidepressant and neuroprotective effects in vivo. Orally active. Blood-brain barrier permeable.
  • Purity
    > 99%
  • CAS Number
    329205-68-7
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Keck TM  et al. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict Biol 19:195-209 (2014). Read more (PubMed: 24001208) »
  • Pollard M  et al. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator. J Psychopharmacol : (2014). Read more (PubMed: 25031220) »
  • Domin H  et al. Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression. Behav Brain Res 273C:23-33 (2014). Read more (PubMed: 25043733) »

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