Overview

  • Product name

  • Description

    Rabbit polyclonal to MTG16
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human MTG16 aa 603-653.
    Database link: NP_005178

  • Positive control

    • Jurkat, 293T, HeLa whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab129444 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 71 kDa.
IP Use at 2-10 µg/mg of lysate.

Target

  • Function

    Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.
    Isoform 2 functions as an A-kinase-anchoring protein.
  • Tissue specificity

    Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
  • Involvement in disease

    Note=A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
  • Sequence similarities

    Belongs to the CBFA2T family.
    Contains 1 MYND-type zinc finger.
    Contains 1 TAFH (NHR1) domain.
  • Cellular localization

    Nucleus > nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm and Nucleus > nucleoplasm. Golgi apparatus membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cbfa2t3 antibody
    • Ccore binding factor runt domain alpha subunit 2 translocated to 3 antibody
    • ETO2 antibody
    • hMTG16 antibody
    • hMTG16a antibody
    • hMTG16b antibody
    • MTG16 antibody
    • MTG16_HUMAN antibody
    • MTG8 related gene 2 antibody
    • MTG8 related protein MTG16a antibody
    • MTG8 related protein MTG16b antibody
    • MTG8-related protein 2 antibody
    • MTGR2 antibody
    • Myeloid translocation gene 8 and 16b antibody
    • Myeloid translocation gene on chromosome 16 protein antibody
    • Protein CBFA2T3 antibody
    • Zinc finger MYND domain-containing protein 4 antibody
    • ZMYND4 antibody
    see all

Images

  • All lanes : Anti-MTG16 antibody (ab129444) at 0.1 µg/ml

    Lane 1 : Jurkat whole cell lysate at 50 µg
    Lane 2 : Jurkat whole cell lysate at 15 µg
    Lane 3 : 293T whole cell lysate at 50 µg
    Lane 4 : HeLa whole cell lysate at 50 µg

    Predicted band size: 71 kDa

  • Detection of MTG16 by Western Blot of Immunprecipitate.
    Lane 1: ab129444 at 1µg/ml staining MTG16 in HeLa whole cell lysate immunoprecipitated using ab129444 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
    Lane 2: Control IgG
    Detection: Chemiluminescence with exposure time of 10 seconds.

References

ab129444 has not yet been referenced specifically in any publications.

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