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    mtgr1-antibody-ab128164.pdf

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Tags & Cell Markers Cell Type Markers Tumor Associated
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Anti-MTGR1 antibody (ab128164)

  • Datasheet
  • SDS
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Western blot - Anti-MTGR1 antibody (ab128164)
  • Immunoprecipitation - Anti-MTGR1 antibody (ab128164)

Key features and details

  • Rabbit polyclonal to MTGR1
  • Suitable for: WB, IP
  • Reacts with: Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-MTGR1 antibody
    See all MTGR1 primary antibodies
  • Description

    Rabbit polyclonal to MTGR1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 554-604 of Human MTGR1 (NP_005084.1).

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7
    Preservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate

    pH 7 to 8
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab128164 was affinity purified using an epitope specific to MTGR1 immobilized on solid support.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Tags & Cell Markers
    • Cell Type Markers
    • Tumor Associated

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa nuclear extract lysate (ab14655)
    • HeLa whole cell lysate (ab29545)
    • Jurkat whole cell lysate (ab7899)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab128164 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/2000 - 1/10000. Predicted molecular weight: 67 kDa.
IP
Use at 2-10 µg/mg of lysate.
Notes
WB
1/2000 - 1/10000. Predicted molecular weight: 67 kDa.
IP
Use at 2-10 µg/mg of lysate.

Target

  • Function

    May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.
  • Tissue specificity

    Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.
  • Sequence similarities

    Belongs to the CBFA2T family.
    Contains 1 MYND-type zinc finger.
    Contains 1 TAFH (NHR1) domain.
  • Cellular localization

    Nucleus.
  • Target information above from: UniProt accession O43439 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 419155 Chicken
    • Entrez Gene: 9139 Human
    • Omim: 601308 Human
    • Omim: 603672 Human
    • SwissProt: 22987 Chicken
    • SwissProt: O43439 Human
    • Unigene: 153934 Human
    • Alternative names

      • AML1 MTG8 antibody
      • cbfa2t2 antibody
      • Core binding factor runt domain alpha subunit 2 translocated to 2 antibody
      • core-binding factor, runt domain, alpha subunit 2 antibody
      • DKFZp313F2116 antibody
      • EHT antibody
      • ETO homolog on chromosome 20 antibody
      • ETO homologous on chromosome 20 antibody
      • MTG 8 like protein antibody
      • MTG 8 related protein 1 antibody
      • MTG8 like protein antibody
      • MTG8 related protein 1 antibody
      • MTG8-like protein antibody
      • MTG8-related protein 1 antibody
      • MTG8R_HUMAN antibody
      • MTGR 1 antibody
      • Myeloid translocation gene related protein 1 antibody
      • Myeloid translocation related protein 1 antibody
      • Myeloid translocation-related protein 1 antibody
      • p85 antibody
      • Protein CBFA2T2 antibody
      • ZMYND 3 antibody
      • ZMYND3 antibody
      see all

    Images

    • Western blot - Anti-MTGR1 antibody (ab128164)
      Western blot - Anti-MTGR1 antibody (ab128164)
      All lanes : Anti-MTGR1 antibody (ab128164) at 0.1 µg/ml

      Lane 1 : 293T whole cell lysate at 50 µg
      Lane 2 : 293T whole cell lysate at 15 µg
      Lane 3 : Jurkat whole cell lysate at 50 µg
      Lane 4 : HeLa whole cell lysate at 50 µg

      Developed using the ECL technique.

      Predicted band size: 67 kDa


      Exposure time: 3 minutes
    • Immunoprecipitation - Anti-MTGR1 antibody (ab128164)
      Immunoprecipitation - Anti-MTGR1 antibody (ab128164)
      Detection of MTGR1 by Western Blot of Immunprecipitate.
      ab128164 at 1 µg/ml staining MTGR1 in 293T whole cell lysate immunoprecipitated using ab128164 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Lane 2: control IgG. Predicted band size : 67 kDa.
      Detection: Chemiluminescence with exposure time of 30 seconds.

    Protocols

    • Western blot protocols
    • Immunoprecipitation protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (2)

    Publishing research using ab128164? Please let us know so that we can cite the reference in this datasheet.

    ab128164 has been referenced in 2 publications.

    • Engqvist H  et al. Validation of Novel Prognostic Biomarkers for Early-Stage Clear-Cell, Endometrioid and Mucinous Ovarian Carcinomas Using Immunohistochemistry. Front Oncol 10:162 (2020). PubMed: 32133296
    • Chen DC  et al. CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma. Cancer Cell Int 17:103 (2017). PubMed: 29162985

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