• Product name

  • Description

    Rabbit polyclonal to MTMR14
  • Host species

  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 264 and 415 of Human MTMR14 (AAH01674; UniProt ID: Q8NCE2 isoform 3).

  • Positive control

    • WB: 293T, A431, Jurkat and Raji cell lysates IHC-P: MCF7 xenograft



Our Abpromise guarantee covers the use of ab102575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: for isoform 3, 60 kDa.
IHC-P 1/100 - 1/500. Antigen retrieval using heat mediated 10mM Citrate buffer or Tris-EDTA buffer (pH 8.0) is recommended.


  • Function

    Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
  • Tissue specificity

    Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
  • Involvement in disease

    Defects in MTMR14 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • Sequence similarities

    Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • Cellular localization

    Cytoplasm. Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • C3orf29 antibody
    • Egg derived tyrosine phosphatase homolog antibody
    • FLJ11546 antibody
    • FLJ22405 antibody
    • FLJ46453 antibody
    • FLJ90311 antibody
    • HCV NS5A transactivated protein 4 splice variant A binding protein 1 antibody
    • HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody
    • hEDTP antibody
    • hJumpy antibody
    • jumpy antibody
    • MTMR 14 antibody
    • MTMR14 antibody
    • MTMRE_HUMAN antibody
    • Myotubularin related protein 14 antibody
    • Myotubularin-related protein 14 antibody
    • NS5ATP4ABP1 antibody
    see all


  • Anti-MTMR14 antibody (ab102575) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size: for isoform 3, 60 kDa

    7.5% SDS PAGE
  • Immunohistochemical analysis of MTMR14 in paraffin embedded MCF7 xenograft, using ab102575 at a 1/250 dilution.


This product has been referenced in:

See all 2 Publications for this product

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