• Product name

  • Description

    Rabbit polyclonal to MTMR14
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide corresponding to Human MTMR14 aa 600 to the C-terminus conjugated to keyhole limpet haemocyanin.
    (Peptide available as ab92660)

  • Positive control

    • This antibody gave a positive signal in the following whole cell lysates: HEK293; HepG2; A549.



Our Abpromise guarantee covers the use of ab76952 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 72 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
    • Tissue specificity

      Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
    • Involvement in disease

      Defects in MTMR14 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
    • Sequence similarities

      Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
    • Cellular localization

      Cytoplasm. Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • C3orf29 antibody
      • Egg derived tyrosine phosphatase homolog antibody
      • FLJ11546 antibody
      • FLJ22405 antibody
      • FLJ46453 antibody
      • FLJ90311 antibody
      • HCV NS5A transactivated protein 4 splice variant A binding protein 1 antibody
      • HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody
      • hEDTP antibody
      • hJumpy antibody
      • jumpy antibody
      • MTMR 14 antibody
      • MTMR14 antibody
      • MTMRE_HUMAN antibody
      • Myotubularin related protein 14 antibody
      • Myotubularin-related protein 14 antibody
      • NS5ATP4ABP1 antibody
      see all


    • All lanes : Anti-MTMR14 antibody (ab76952) at 1 µg/ml

      Lane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate
      Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate
      Lane 3 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate

      Lysates/proteins at 10 µg per lane.

      All lanes : Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

      Developed using the ECL technique.

      Performed under reducing conditions.

      Predicted band size: 72 kDa
      Observed band size: 90 kDa
      why is the actual band size different from the predicted?

      Exposure time: 20 minutes

      MTMR14 contains a number of potential glycosylation sites (SwissProt) which may explain its migration at a higher molecular weight than predicted.


    ab76952 has not yet been referenced specifically in any publications.

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