Overview

  • Product name

  • Description

    Rabbit polyclonal to MTMR2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC - Wholemountmore details
  • Species reactivity

    Reacts with: Zebrafish
  • Immunogen

    Recombinant fragment within Zebrafish MTMR2 aa 217-523. The exact sequence is proprietary.
    Database link: A0JMK5

  • Positive control

    • Zebrafish embryos.

Properties

Applications

Our Abpromise guarantee covers the use of ab211129 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC - Wholemount 1/100 - 1/500.

Target

  • Function

    Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate.
  • Involvement in disease

    Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1) [MIM:601382]. CMT4B1 is a recessive, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
  • Sequence similarities

    Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
    Contains 1 GRAM domain.
    Contains 1 myotubularin phosphatase domain.
  • Domain

    The coiled-coil domain mediates interaction with SBF2.
  • Cellular localization

    Cytoplasm. Membrane. Partly associated with membranes.
  • Information by UniProt
  • Database links

    • Alternative names

      • CMT4B antibody
      • CMT4B1 antibody
      • KIAA1073 antibody
      • MTMR2 antibody
      • MTMR2_HUMAN antibody
      • Myotubularin related protein 2 antibody
      • Myotubularin-related protein 2 antibody
      • OTTHUMP00000204445 antibody
      • OTTHUMP00000204446 antibody
      • OTTHUMP00000204447 antibody
      • OTTHUMP00000204448 antibody
      • Phosphatidylinositol 3 phosphate phosphatase antibody
      • Phosphatidylinositol 3,5 bisphosphate 3 phosphatase antibody
      see all

    Images

    • Whole mount immunohistochemical analysis of paraformaldehyde-fixed zebrafish embryo labeling MTMR2 with ab211129 at 1/200 dilution.

    References

    ab211129 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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