Key features and details
- Rabbit polyclonal to MTMR2
- Suitable for: IHC - Wholemount
- Reacts with: Zebrafish
- Isotype: IgG
Product nameAnti-MTMR2 antibody
See all MTMR2 primary antibodies
DescriptionRabbit polyclonal to MTMR2
Tested applicationsSuitable for: IHC - Wholemountmore details
Species reactivityReacts with: Zebrafish
Recombinant fragment within Zebrafish MTMR2 aa 217-523. The exact sequence is proprietary.
Database link: A0JMK5
- Zebrafish embryos.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab211129 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC - Wholemount||1/100 - 1/500.|
FunctionPhosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate.
Involvement in diseaseDefects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1) [MIM:601382]. CMT4B1 is a recessive, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Contains 1 GRAM domain.
Contains 1 myotubularin phosphatase domain.
DomainThe coiled-coil domain mediates interaction with SBF2.
Cellular localizationCytoplasm. Membrane. Partly associated with membranes.
- Information by UniProt
- CMT4B antibody
- CMT4B1 antibody
- KIAA1073 antibody
ab211129 has not yet been referenced specifically in any publications.