Anti-MTP18 antibody (ab198217)
Key features and details
- Rabbit polyclonal to MTP18
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-MTP18 antibody
See all MTP18 primary antibodies -
Description
Rabbit polyclonal to MTP18 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat -
Immunogen
Recombinant fragment (GST-tag) corresponding to Human MTP18 (internal sequence). BC046132
Database link: Q9UDX5 -
Positive control
- Mouse heart, muscle, liver and kidney tissue lysates; HeLa and HepG2 whole cell lysate (ab7900); Human cervical cancer tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab198217 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/50 - 1/200.
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WB | (1) |
1/500 - 1/2000. Predicted molecular weight: 18 kDa.
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Notes |
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IHC-P
1/50 - 1/200. |
WB
1/500 - 1/2000. Predicted molecular weight: 18 kDa. |
Target
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Function
Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis. -
Sequence similarities
Belongs to the MTFP1 family. -
Cellular localization
Mitochondrion inner membrane. - Information by UniProt
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Database links
- Entrez Gene: 51537 Human
- Entrez Gene: 67900 Mouse
- Omim: 610235 Human
- SwissProt: Q9UDX5 Human
- SwissProt: Q9CRB8 Mouse
- Unigene: 713636 Human
- Unigene: 41719 Mouse
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Alternative names
- HSPC 242 antibody
- HSPC242 antibody
- Mitochondrial 18 kDa protein antibody
see all
Images
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Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling MTP18 with ab198217 at 1/30 dilution.
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All lanes : Anti-MTP18 antibody (ab198217) at 1/450 dilution
Lane 1 : Mouse heart tissue lysate
Lane 2 : Mouse muscle tissue lysate
Lane 3 : HeLa cell lysate
Lane 4 : Mouse liver tissue lysate
Lane 5 : Mouse kidney tissue lysate
Lane 6 : HepG2 cell lysate
Lysates/proteins at 40 µg per lane.
Predicted band size: 18 kDa
Exposure time: 5 seconds10% SDS-PAGE.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab198217 has been referenced in 5 publications.
- Kreymerman A et al. MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses. Sci Rep 9:10669 (2019). PubMed: 31337818
- Long RT et al. Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells. Mol Cells 42:893-905 (2019). PubMed: 31822044
- Wei Q et al. MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury. J Clin Invest 128:5448-5464 (2018). PubMed: 30325740
- Aung LHH et al. Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis. Oncotarget 8:56582-56597 (2017). WB . PubMed: 28915614
- Morita M et al. mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Mol Cell 67:922-935.e5 (2017). PubMed: 28918902